The initials TPK may refer to:
- Tai Ping Koon Restaurant
- Te Puni Kōkiri, the Ministry of Māori Development, New Zealand
- Total party kill in role-playing games
- Turun Pallokerho, football club in Turku, Finland
- TPK algorithm, a simple program introduced by Luis Trabb Pardo and Donald Knuth, to compare early programming languages
- Traditional Phenological Knowledge