TRAPPC3

Trafficking protein particle complex subunit 3 is a protein that in humans is encoded by the TRAPPC3 gene.

TRAPPC3
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1SZ7, 2C0J, 2CFH, 3KXC
Identifiers
Aliases	TRAPPC3, BET3, trafficking protein particle complex 3, trafficking protein particle complex subunit 3
External IDs	OMIM: 610955; MGI: 1351486; HomoloGene: 6399; GeneCards: TRAPPC3; OMA:TRAPPC3 - orthologs
Gene location (Human) Chr. Chromosome 1 (human) Band 1p34.3 Start 36,136,570 bp End 36,156,053 bp
Gene location (Mouse) Chr. Chromosome 4 (mouse) Band 4|4 D2.2 Start 126,156,118 bp End 126,169,676 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in right adrenal gland right adrenal cortex left adrenal gland left adrenal cortex right lobe of thyroid gland islet of Langerhans left lobe of thyroid gland right coronary artery muscle layer of sigmoid colon left testis Top expressed in calvaria neural layer of retina medial ganglionic eminence cerebellar cortex dentate gyrus of hippocampal formation granule cell right kidney stroma of bone marrow choroid plexus lip Epithelium of choroid plexus More reference expression data BioGPS More reference expression data
Gene ontology Molecular function protein binding Cellular component Golgi apparatus endoplasmic reticulum Golgi membrane cytosol TRAPP complex cis-Golgi network membrane Biological process COPII vesicle coating vesicle-mediated transport Golgi vesicle transport endoplasmic reticulum to Golgi vesicle-mediated transport intra-Golgi vesicle-mediated transport Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 27095 27096 Ensembl ENSG00000054116 ENSMUSG00000028847 UniProt O43617 O55013 RefSeq (mRNA) NM_001270894 NM_001270895 NM_001270896 NM_001270897 NM_014408 NM_013718 RefSeq (protein) NP_001257823 NP_001257824 NP_001257825 NP_001257826 NP_055223 NP_038746 Location (UCSC) Chr 1: 36.14 – 36.16 Mb Chr 4: 126.16 – 126.17 Mb PubMed search
Wikidata
View/Edit Human View/Edit Mouse

Further reading

• Yu W, Andersson B, Worley KC, et al. (1997). "Large-Scale Concatenation cDNA Sequencing". Genome Res. 7 (4): 353–8. doi:10.1101/gr.7.4.353. PMC 139146. PMID 9110174.
• Sacher M, Jiang Y, Barrowman J, et al. (1998). "TRAPP, a highly conserved novel complex on the cis-Golgi that mediates vesicle docking and fusion". EMBO J. 17 (9): 2494–503. doi:10.1093/emboj/17.9.2494. PMC 1170591. PMID 9564032.
• Barrowman J, Sacher M, Ferro-Novick S (2000). "TRAPP stably associates with the Golgi and is required for vesicle docking". EMBO J. 19 (5): 862–9. doi:10.1093/emboj/19.5.862. PMC 305626. PMID 10698928.
• Gavin AC, Bösche M, Krause R, et al. (2002). "Functional organization of the yeast proteome by systematic analysis of protein complexes". Nature. 415 (6868): 141–7. Bibcode:2002Natur.415..141G. doi:10.1038/415141a. PMID 11805826. S2CID 4425555.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Kim YG, Sohn EJ, Seo J, et al. (2005). "Crystal structure of bet3 reveals a novel mechanism for Golgi localization of tethering factor TRAPP". Nat. Struct. Mol. Biol. 12 (1): 38–45. doi:10.1038/nsmb871. PMID 15608655. S2CID 22597154.
• Turnbull AP, Kümmel D, Prinz B, et al. (2005). "Structure of palmitoylated BET3: insights into TRAPP complex assembly and membrane localization". EMBO J. 24 (5): 875–84. doi:10.1038/sj.emboj.7600565. PMC 554119. PMID 15692564.
• Loh E, Peter F, Subramaniam VN, Hong W (2005). "Mammalian Bet3 functions as a cytosolic factor participating in transport from the ER to the Golgi apparatus" (PDF). J. Cell Sci. 118 (Pt 6): 1209–22. doi:10.1242/jcs.01723. PMID 15728249. S2CID 3092909.
• Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID 16189514. S2CID 4427026.
• Kim MS, Yi MJ, Lee KH, et al. (2006). "Biochemical and crystallographic studies reveal a specific interaction between TRAPP subunits Trs33p and Bet3p". Traffic. 6 (12): 1183–95. doi:10.1111/j.1600-0854.2005.00352.x. PMID 16262728. S2CID 24273412.
• Kümmel D, Müller JJ, Roske Y, et al. (2006). "Structure of the Bet3-Tpc6B core of TRAPP: two Tpc6 paralogs form trimeric complexes with Bet3 and Mum2". J. Mol. Biol. 361 (1): 22–32. doi:10.1016/j.jmb.2006.06.012. PMID 16828797.
• Yu S, Satoh A, Pypaert M, et al. (2006). "mBet3p is required for homotypic COPII vesicle tethering in mammalian cells". J. Cell Biol. 174 (3): 359–68. doi:10.1083/jcb.200603044. PMC 2064232. PMID 16880271.
• Kümmel D, Heinemann U, Veit M (2006). "Unique self-palmitoylation activity of the transport protein particle component Bet3: A mechanism required for protein stability". Proc. Natl. Acad. Sci. U.S.A. 103 (34): 12701–6. Bibcode:2006PNAS..10312701K. doi:10.1073/pnas.0603513103. PMC 1562543. PMID 16908848.