TRIM62, also called DEAR1 (for ductal epithelium–associated RING chromosome 1),[1] is a protein in the tripartite motif family. In human it is encoded by the gene TRIM62.[2] TRIM62 is involved in the morphogenesis of the mammary gland, and loss of TRIM62 gene expression in breast is associated with a higher risk of recurrence in early-onset breast cancer.[1]
References
edit- ^ a b Lott ST, Chen N, Chandler DS, Yang Q, Wang L, et al. (2009). Minna JD (ed.). "DEAR1 Is a Dominant Regulator of Acinar Morphogenesis and an Independent Predictor of Local Recurrence-Free Survival in Early-Onset Breast Cancer". PLOS Medicine. 6 (5): e1000068. doi:10.1371/journal.pmed.1000068. PMC 2673042. PMID 19536326.
- ^ "TRIM62 tripartite motif-containing 62 [ Homo sapiens ]". Entrez Gene. Retrieved 1 Jun 2009.
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