TRMT12

TRMT12
Identifiers
Aliases	TRMT12, TRM12, TYW2, tRNA methyltransferase 12 homolog
External IDs	OMIM: 611244; MGI: 1915510; HomoloGene: 32379; GeneCards: TRMT12; OMA:TRMT12 - orthologs
Gene location (Human)
Chr.	Chromosome 8 (human)
End	124,462,150 bp
Gene location (Mouse)
Chr.	Chromosome 15 (mouse)
End	58,748,976 bp
RNA expression pattern
	Top expressed in
	sperm; ; endothelial cell; ; Epithelium of choroid plexus; ; monocyte; ; islet of Langerhans; ; Achilles tendon; ; testicle; ; gastrocnemius muscle; ; secondary oocyte; ; amniotic fluid;
	Top expressed in
	superior cervical ganglion; ; zygote; ; granulocyte; ; right kidney; ; tail of embryo; ; embryo; ; ventricular zone; ; proximal tubule; ; dentate gyrus of hippocampal formation granule cell; ; muscle of thigh;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	protein binding; transferase activity; tRNA 4-demethylwyosine alpha-amino-alpha-carboxypropyltransferase activity; tRNA methyltransferase activity;
Cellular component	cytoplasm;
Biological process	tRNA processing; tRNA methylation; wybutosine biosynthetic process;
	Sources:Amigo / QuickGO
Orthologs
	55039
	68260
	ENSG00000183665
	ENSMUSG00000037085
	Q53H54
	Q8BG71
	NM_017956
	NM_026642
	NP_060426
	NP_080918
	Wikidata
View/Edit Human	View/Edit Mouse

tRNA wybutosine-synthesizing protein 2 homolog is a protein that in humans is encoded by the TRMT12 gene.^[5]^[6]^[7]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000183665 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000037085 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Kalhor HR, Penjwini M, Clarke S (Jul 2005). "A novel methyltransferase required for the formation of the hypermodified nucleoside wybutosine in eucaryotic tRNA". Biochem Biophys Res Commun. 334 (2): 433–40. doi:10.1016/j.bbrc.2005.06.111. PMID 16005430.
^ Noma A, Suzuki T (Dec 2006). "Ribonucleome analysis identified enzyme genes responsible for wybutosine synthesis". Nucleic Acids Symp Ser (Oxf). 50 (50): 65–6. doi:10.1093/nass/nrl032. PMID 17150819.
^ "Entrez Gene: TRMT12 tRNA methyltransferase 12 homolog (S. cerevisiae)".

Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Suzuki Y, Yamashita R, Shirota M, et al. (2004). "Sequence comparison of human and mouse genes reveals a homologous block structure in the promoter regions". Genome Res. 14 (9): 1711–8. doi:10.1101/gr.2435604. PMC 515316. PMID 15342556.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Rodriguez V, Chen Y, Elkahloun A, et al. (2007). "Chromosome 8 BAC array comparative genomic hybridization and expression analysis identify amplification and overexpression of TRMT12 in breast cancer". Genes Chromosomes Cancer. 46 (7): 694–707. doi:10.1002/gcc.20454. PMID 17440925. S2CID 36237771.

This article on a gene on human chromosome 8 is a stub. You can help Wikipedia by expanding it.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000183665 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000037085 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid16005430-5] Kalhor HR, Penjwini M, Clarke S (Jul 2005). "A novel methyltransferase required for the formation of the hypermodified nucleoside wybutosine in eucaryotic tRNA". Biochem Biophys Res Commun. 334 (2): 433–40. doi:10.1016/j.bbrc.2005.06.111. PMID 16005430.

[pmid17150819-6] Noma A, Suzuki T (Dec 2006). "Ribonucleome analysis identified enzyme genes responsible for wybutosine synthesis". Nucleic Acids Symp Ser (Oxf). 50 (50): 65–6. doi:10.1093/nass/nrl032. PMID 17150819.

[entrez-7] "Entrez Gene: TRMT12 tRNA methyltransferase 12 homolog (S. cerevisiae)".

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TRMT12

References

Further reading