TRNA-dihydrouridine16/17 synthase (NAD(P)+) (EC 1.3.1.88, Dus1p, tRNA-dihydrouridine synthase 1) is an enzyme with systematic name tRNA-5,6-dihydrouracil16/17:NAD(P)+ oxidoreductase.[1][2] This enzyme catalyses the following chemical reaction
| TRNA-dihydrouridine16/17 synthase (NAD(P)+) | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| EC no. | 1.3.1.88 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| |||||||||
- (1) 5,6-dihydrouracil16 in tRNA + NAD(P)+ uracil16 in tRNA + NAD(P)H + H+
- (2) 5,6-dihydrouracil17 in tRNA + NAD(P)+ uracil17 in tRNA + NAD(P)H + H+
This enzyme specifically modifies uracil16 and uracil17 in tRNA.
References
edit- ^ Xing F, Hiley SL, Hughes TR, Phizicky EM (April 2004). "The specificities of four yeast dihydrouridine synthases for cytoplasmic tRNAs". The Journal of Biological Chemistry. 279 (17): 17850–60. doi:10.1074/jbc.M401221200. PMID 14970222.
- ^ Xing F, Martzen MR, Phizicky EM (March 2002). "A conserved family of Saccharomyces cerevisiae synthases effects dihydrouridine modification of tRNA". RNA. 8 (3): 370–81. doi:10.1017/S1355838202029825. PMC 1370258. PMID 12003496.
External links
edit- TRNA-dihydrouridine16/17+synthase+(NAD(P)+) at the U.S. National Library of Medicine Medical Subject Headings (MeSH)
