TRNA-dihydrouridine20a/20b synthase (NAD(P)+)

TRNA-dihydrouridine20a/20b synthase (NAD(P)+) (EC 1.3.1.90, Dus4p) is an enzyme with systematic name tRNA-5,6-dihydrouracil20a/20b:NAD(P)+ oxidoreductase.[1] This enzyme catalyses the following chemical reaction

TRNA-dihydrouridine20a/20b synthase (NAD(P)+)
Identifiers
EC no.1.3.1.90
Databases
IntEnzIntEnz view
BRENDABRENDA entry
ExPASyNiceZyme view
KEGGKEGG entry
MetaCycmetabolic pathway
PRIAMprofile
PDB structuresRCSB PDB PDBe PDBsum
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PMCarticles
PubMedarticles
NCBIproteins
(1) 5,6-dihydrouracil20a in tRNA + NAD(P)+ uracil20a in tRNA + NAD(P)H + H+
(2) 5,6-dihydrouracil20b in tRNA + NAD(P)+ uracil20b in tRNA + NAD(P)H + H+

A flavoenzyme. The enzyme specifically modifies uracil20a and uracil20b in tRNA.

References

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  1. ^ Xing F, Hiley SL, Hughes TR, Phizicky EM (April 2004). "The specificities of four yeast dihydrouridine synthases for cytoplasmic tRNAs". The Journal of Biological Chemistry. 279 (17): 17850–60. doi:10.1074/jbc.M401221200. PMID 14970222.
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