TRNA (guanine10-N2)-methyltransferase (EC 2.1.1.214, (m2G10) methyltransferase, Trm11-Trm112 complex) is an enzyme with systematic name S-adenosyl-L-methionine:tRNA (guanine10-N2)-methyltransferase.[1] This enzyme catalyses the following chemical reaction
| TRNA (guanine10-N2)-methyltransferase | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| EC no. | 2.1.1.214 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| |||||||||
- S-adenosyl-L-methionine + guanine10 in tRNA S-adenosyl-L-homocysteine + N2-methylguanine10 in tRNA
tRNA (guanine10-N2)-methyltransferase from yeast does not catalyse the methylation from N2-methylguanine10 to N2-dimethylguanine10 in tRNA.
References
edit- ^ Purushothaman SK, Bujnicki JM, Grosjean H, Lapeyre B (June 2005). "Trm11p and Trm112p are both required for the formation of 2-methylguanosine at position 10 in yeast tRNA". Molecular and Cellular Biology. 25 (11): 4359–70. doi:10.1128/MCB.25.11.4359-4370.2005. PMC 1140639. PMID 15899842.
External links
edit- TRNA+(guanine10-N2)-methyltransferase at the U.S. National Library of Medicine Medical Subject Headings (MeSH)
