TRNA (guanine26-N2/guanine27-N2)-dimethyltransferase (EC 2.1.1.215, Trm1, tRNA (N2,N2-guanine)-dimethyltransferase, tRNA (m2(2G26) methyltransferase, Trm1[tRNA (m2(2)G26) methyltransferase]) is an enzyme with systematic name S-adenosyl-L-methionine:tRNA (guanine26-N2/guanine27-N2)-dimethyltransferase.[1] This enzyme catalyses the following chemical reaction
| TRNA (guanine26-N2/guanine27-N2)-dimethyltransferase | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| EC no. | 2.1.1.215 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| |||||||||
- 4 S-adenosyl-L-methionine + guanine26/guanine27 in tRNA 4 S-adenosyl-L-homocysteine + N2-dimethylguanine26/N2-dimethylguanine27 in tRNA
The enzyme from Aquifex aeolicus is similar to the TRM1 methyltransferases of archaea and eukarya.
References
edit- ^ Awai T, Kimura S, Tomikawa C, Ochi A, Bessho Y, Yokoyama S, Ohno S, Nishikawa K, Yokogawa T, Suzuki T, Hori H (July 2009). "Aquifex aeolicus tRNA (N2,N2-guanine)-dimethyltransferase (Trm1) catalyzes transfer of methyl groups not only to guanine 26 but also to guanine 27 in tRNA". The Journal of Biological Chemistry. 284 (31): 20467–78. doi:10.1074/jbc.m109.020024. PMC 2742811. PMID 19491098.
External links
edit- TRNA+(guanine26-N2/guanine27-N2)-dimethyltransferase at the U.S. National Library of Medicine Medical Subject Headings (MeSH)
