TRNA (guanine6-N2)-methyltransferase (EC 2.1.1.256, methyltransferase Trm14, m2G6 methyltransferase) is an enzyme with systematic name S-adenosyl-L-methionine:tRNA (guanine6-N2)-methyltransferase.[1] This enzyme catalyses the following chemical reaction
| TRNA (guanine6-N2)-methyltransferase | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| EC no. | 2.1.1.256 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| |||||||||
- S-adenosyl-L-methionine + guanine6 in tRNA S-adenosyl-L-homocysteine + N2-methylguanine6 in tRNA
The enzyme specifically methylates guanine6 at N2 in tRNA.
References
edit- ^ Menezes S, Gaston KW, Krivos KL, Apolinario EE, Reich NO, Sowers KR, Limbach PA, Perona JJ (September 2011). "Formation of m2G6 in Methanocaldococcus jannaschii tRNA catalyzed by the novel methyltransferase Trm14". Nucleic Acids Research. 39 (17): 7641–55. doi:10.1093/nar/gkr475. PMC 3177210. PMID 21693558.
External links
edit- TRNA+(guanine6-N2)-methyltransferase at the U.S. National Library of Medicine Medical Subject Headings (MeSH)
