TRNA (pseudouridine54-N1)-methyltransferase

TRNA (pseudouridine54-N1)-methyltransferase (EC 2.1.1.257, TrmY, m1Psi methyltransferase) is an enzyme with systematic name S-adenosyl-L-methionine:tRNA (pseudouridine54-N1)-methyltransferase.[1][2][3] This enzyme catalyses the following chemical reaction

TRNA (pseudouridine54-N1)-methyltransferase
Identifiers
EC no.2.1.1.257
Databases
IntEnzIntEnz view
BRENDABRENDA entry
ExPASyNiceZyme view
KEGGKEGG entry
MetaCycmetabolic pathway
PRIAMprofile
PDB structuresRCSB PDB PDBe PDBsum
Search
PMCarticles
PubMedarticles
NCBIproteins
S-adenosyl-L-methionine + pseudouridine54 in tRNA S-adenosyl-L-homocysteine + N1-methylpseudouridine54 in tRNA

This archaeal enzyme is specific for the 54 position.

References

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  1. ^ Chen HY, Yuan YA (December 2010). "Crystal structure of Mj1640/DUF358 protein reveals a putative SPOUT-class RNA methyltransferase". Journal of Molecular Cell Biology. 2 (6): 366–74. doi:10.1093/jmcb/mjq034. PMID 21098051.
  2. ^ Wurm JP, Griese M, Bahr U, Held M, Heckel A, Karas M, Soppa J, Wöhnert J (March 2012). "Identification of the enzyme responsible for N1-methylation of pseudouridine 54 in archaeal tRNAs". RNA. 18 (3): 412–20. doi:10.1261/rna.028498.111. PMC 3285930. PMID 22274954.
  3. ^ Chatterjee K, Blaby IK, Thiaville PC, Majumder M, Grosjean H, Yuan YA, Gupta R, de Crécy-Lagard V (March 2012). "The archaeal COG1901/DUF358 SPOUT-methyltransferase members, together with pseudouridine synthase Pus10, catalyze the formation of 1-methylpseudouridine at position 54 of tRNA". RNA. 18 (3): 421–33. doi:10.1261/rna.030841.111. PMC 3285931. PMID 22274953.
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