TSC22 domain family protein 1 is a protein that in humans is encoded by the TSC22D1 gene.[5][6]

TSC22D1
Identifiers
AliasesTSC22D1, Ptg-2, TGFB1I4, TSC22, TSC22 domain family member 1
External IDsOMIM: 607715; MGI: 109127; HomoloGene: 7573; GeneCards: TSC22D1; OMA:TSC22D1 - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001243797
NM_001243798
NM_001243799
NM_006022
NM_183422

NM_001177751
NM_009366
NM_207652
NM_001310646
NM_001310647

RefSeq (protein)

NP_001230726
NP_001230727
NP_001230728
NP_006013
NP_904358

NP_001171222
NP_001297575
NP_001297576
NP_033392
NP_997535

Location (UCSC)Chr 13: 44.43 – 44.58 MbChr 14: 76.65 – 76.75 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

TSC22 encodes a transcription factor and belongs to the large family of early response genes.[7]

TSC22D1 forms homodimers via its conserved leucine zipper domain and heterodimerizes with TSC22D4. TSC22D1 has transcriptional repressor activity.[8]

References

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  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000102804Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000022010Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Jay P, Ji JW, Marsollier C, Taviaux S, Berge-Lefranc JL, Berta P (Jul 1996). "Cloning of the human homologue of the TGF beta-stimulated clone 22 gene". Biochem Biophys Res Commun. 222 (3): 821–6. doi:10.1006/bbrc.1996.0825. PMID 8651929.
  6. ^ Ohta S, Shimekake Y, Nagata K (Mar 1997). "Molecular cloning and characterization of a transcription factor for the C-type natriuretic peptide gene promoter". Eur J Biochem. 242 (3): 460–6. doi:10.1111/j.1432-1033.1996.460rr.x. PMID 9022669.
  7. ^ "Entrez Gene: TSC22D1 TSC22 domain family, member 1".
  8. ^ Kester HA, Blanchetot C, den Hertog J, van der Saag PT, van der Burg B (September 1999). "Transforming growth factor-beta-stimulated clone-22 is a member of a family of leucine zipper proteins that can homo- and heterodimerize and has transcriptional repressor activity". J. Biol. Chem. 274 (39): 27439–47. doi:10.1074/jbc.274.39.27439. PMID 10488076.

Further reading

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This article incorporates text from the United States National Library of Medicine, which is in the public domain.