TTB may refer to the following:
- Alcohol and Tobacco Tax and Trade Bureau
- Ticking time bomb scenario
- Tooele Transcript-Bulletin
- Tortolì Airport
- Twin Traction Beam
- Türk Ticaret Bankası, a defunct Turkish bank
- Telegraphic transfer buying rate, an exchange rate convention in Japan
- Top to bottom, a group of writing systems
- Music
- The Trinity Band, an English soul quintet formed in 2004
- Trigger the Bloodshed, an English music group formed in 2006
- Tedeschi Trucks Band, a blues group from Florida
- Television
- Time Traveling Bong a miniseries that aired on Comedy Central