TTBK1

Tau tubulin kinase 1 is a protein that in humans is encoded by the TTBK1 gene.

TTBK1
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 4BTJ, 4BTK, 4BTM, 4NFM, 4NFN
Identifiers
Aliases	TTBK1, BDTK, tau tubulin kinase 1
External IDs	MGI: 2147036; HomoloGene: 50342; GeneCards: TTBK1; OMA:TTBK1 - orthologs
Gene location (Human) Chr. Chromosome 6 (human) Band 6p21.1 Start 43,243,481 bp End 43,288,258 bp
Gene location (Mouse) Chr. Chromosome 17 (mouse) Band 17|17 C Start 46,753,374 bp End 46,798,601 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in lateral nuclear group of thalamus prefrontal cortex postcentral gyrus right frontal lobe right hemisphere of cerebellum superior frontal gyrus anterior cingulate cortex entorhinal cortex Brodmann area 9 amygdala Top expressed in superior frontal gyrus primary visual cortex seminiferous tubule dentate gyrus of hippocampal formation granule cell cerebellar cortex Rostral migratory stream primary motor cortex cingulate gyrus spermatid subiculum More reference expression data BioGPS n/a
Gene ontology Molecular function transferase activity nucleotide binding protein kinase activity protein serine/threonine kinase activity ATP binding kinase activity tau protein binding tau-protein kinase activity Cellular component cytoplasm nucleus nucleoplasm cytosol microtubule associated complex soma perinuclear region of cytoplasm Biological process protein phosphorylation peptidyl-serine phosphorylation substantia nigra development phosphorylation regulation of cell shape learning or memory positive regulation of gene expression negative regulation of gene expression peptidyl-threonine phosphorylation peptidyl-tyrosine phosphorylation negative regulation of protein binding positive regulation of protein polymerization positive regulation of astrocyte activation positive regulation of microglial cell activation positive regulation of cyclin-dependent protein kinase activity positive regulation of cysteine-type endopeptidase activity Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 84630 106763 Ensembl ENSG00000146216 ENSMUSG00000015599 UniProt Q5TCY1 Q6PCN3 RefSeq (mRNA) NM_032538 NM_001162864 NM_175351 RefSeq (protein) NP_115927 NP_001156336 Location (UCSC) Chr 6: 43.24 – 43.29 Mb Chr 17: 46.75 – 46.8 Mb PubMed search
Wikidata
View/Edit Human View/Edit Mouse

Further reading

• Sato S, Xu J, Okuyama S, Martinez LB, Walsh SM, Jacobsen MT, Swan RJ, Schlautman JD, Ciborowski P, Ikezu T (2008). "Spatial learning impairment, enhanced CDK5/p35 activity, and downregulation of NMDA receptor expression in transgenic mice expressing tau-tubulin kinase 1". J. Neurosci. 28 (53): 14511–21. doi:10.1523/JNEUROSCI.3417-08.2008. PMC 6671237. PMID 19118186.
• Vázquez-Higuera JL, Martínez-García A, Sánchez-Juan P, Rodríguez-Rodríguez E, Mateo I, Pozueta A, Frank A, Valdivieso F, Berciano J, Bullido MJ, Combarros O (2011). "Genetic variations in tau-tubulin kinase-1 are linked to Alzheimer's disease in a Spanish case-control cohort". Neurobiol. Aging. 32 (3): 550.e5–9. doi:10.1016/j.neurobiolaging.2009.12.021. PMID 20096481. S2CID 5587797.
• Vázquez-Higuera JL, Martínez-García A, Sánchez-Juan P, Rodríguez-Rodríguez E, Mateo I, Pozueta A, Frank A, Valdivieso F, Berciano J, Bullido MJ, Combarros O (2011). "Genetic variations in tau-tubulin kinase-1 are linked to Alzheimer's disease in a Spanish case-control cohort". Neurobiol. Aging. 32 (3): 550.e5–9. doi:10.1016/j.neurobiolaging.2009.12.021. PMID 20096481. S2CID 5587797.
• Yu NN, Yu JT, Xiao JT, Zhang HW, Lu RC, Jiang H, Xing ZH, Tan L (2011). "Tau-tubulin kinase-1 gene variants are associated with Alzheimer's disease in Han Chinese". Neurosci. Lett. 491 (1): 83–6. doi:10.1016/j.neulet.2011.01.011. PMID 21219968. S2CID 6421145.
• Lund H, Cowburn RF, Gustafsson E, Strömberg K, Svensson A, Dahllund L, Malinowsky D, Sunnemark D (2013). "Tau-tubulin kinase 1 expression, phosphorylation and co-localization with phospho-Ser422 tau in the Alzheimer's disease brain". Brain Pathol. 23 (4): 378–89. doi:10.1111/bpa.12001. PMC 8029021. PMID 23088643. S2CID 30089308.
• Kiefer SE, Chang CJ, Kimura SR, Gao M, Xie D, Zhang Y, Zhang G, Gill MB, Mastalerz H, Thompson LA, Cacace AM, Sheriff S (2014). "The structure of human tau-tubulin kinase 1 both in the apo form and in complex with an inhibitor". Acta Crystallogr F. 70 (Pt 2): 173–81. doi:10.1107/S2053230X14000144. PMC 3936456. PMID 24637750.