TTFB (4,5,6,7-Tetrachloro-2-trifluoromethylbenzimidazole) is a halogenated benzimidazole derivative that acts as an uncoupling agent.[2]

TTFB
Identifiers
3D model (JSmol)
ChEBI
ChEMBL
ChemSpider
KEGG
  • InChI=1S/C8HCl4F3N2/c9-1-2(10)4(12)6-5(3(1)11)16-7(17-6)8(13,14)15/h(H,16,17)
    Key: QLKDMIUEWFNEPV-UHFFFAOYSA-N
  • C12=C(C(=C(C(=C1Cl)Cl)Cl)Cl)N=C(N2)C(F)(F)F
Properties
C8HCl4F3N2
Molar mass 323.91 g·mol−1
Hazards
Lethal dose or concentration (LD, LC):
23 mg/kg (mice, intraperitoneal)[1]
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).

See also

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References

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  1. ^ Ilivicky, J; Casida, JE (June 1969). "Uncoupling action of 2,4-dinitrophenols, 2-trifluoromethylbenzimidazoles and certain other pesticide chemicals upon mitochondria from different sources and its relation to toxicity". Biochemical Pharmacology. 18 (6): 1389–401. doi:10.1016/0006-2952(69)90252-4. PMID 5799112.
  2. ^ Beechey, RB (January 1966). "The uncoupling of respiratory-chain phosphorylation by 4,5,6,7-tetrachloro-2-trifluoromethylbenzimidazole". The Biochemical Journal. 98 (1): 284–9. doi:10.1042/bj0980284. PMC 1264827. PMID 4223043.