TUBA1B

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Talk

Tubulin alpha-1B chain is a protein that in humans is encoded by the TUBA1B gene.^[5]^[6]^[7]

TUBA1B

Available structures

Ortholog search: PDBe RCSB

List of PDB id codes
2E4H, 4TV8, 3RYI, 3JAR, 4TUY, 4TV9, 4YJ2, 3RYH, 3JAK, 3JAS, 4F61, 3UT5, 4O4J, 4YJ3, 4EB6, 4WBN, 3JAW, 4O2A, 3RYF, 3JAL, 4O4H, 4LNU, 3J8Y, 4IIJ, 4O4I, 3RYC, 4O4L, 4O2B, 4I50, 3JAT, 4HNA, 4F6R, 3J8X, 5CA0, 5ITZ, 5JQG, 5IJ0, 5FNV, 5IJ9

Identifiers

TUBA1B, K-ALPHA-1, tubulin alpha 1b

External IDs

OMIM: 602530; MGI: 107804; HomoloGene: 134527; GeneCards: TUBA1B; OMA:TUBA1B - orthologs

Gene location (Human)

Chr.	Chromosome 12 (human)^[1]

Band	12q13.12	Start	49,127,782 bp^[1]
Band	12q13.12	End	49,131,397 bp^[1]

Gene location (Mouse)

Chr.	Chromosome 15 (mouse)^[2]

Band	15\|15 F1	Start	98,829,306 bp^[2]
Band	15\|15 F1	End	98,832,446 bp^[2]

RNA expression pattern

Human

Mouse (ortholog)

Top expressed in

ventricular zone

frontal pole

superior frontal gyrus

prefrontal cortex

thalamus

Brodmann area 10

right frontal lobe

dorsolateral prefrontal cortex

cingulate gyrus

anterior cingulate cortex

Top expressed in

ventricular zone

hypothalamus

tail of embryo

mesencephalon

epiblast

neural tube

genital tubercle

dentate gyrus of hippocampal formation granule cell

cerebellar cortex

primary visual cortex

More reference expression data

n/a

Gene ontology
Molecular function	nucleotide binding GTP binding structural molecule activity structural constituent of cytoskeleton protein binding GTPase activity double-stranded RNA binding ubiquitin protein ligase binding
Cellular component	cytoplasm myelin sheath cytoplasmic microtubule microtubule cytoskeleton microtubule cytoskeleton membrane raft
Biological process	cellular response to interleukin-4 cytoskeleton-dependent intracellular transport cell division microtubule-based process microtubule cytoskeleton organization mitotic cell cycle
Sources:Amigo / QuickGO

Species

Human

Mouse


10376


22143


ENSG00000123416


ENSMUSG00000023004


P68363


P05213

RefSeq (mRNA)


NM_006082


NM_011654

RefSeq (protein)


NP_006073


NP_035784

Location (UCSC)

Chr 12: 49.13 – 49.13 Mb

Chr 15: 98.83 – 98.83 Mb

PubMed search

^[3]

^[4]

View/Edit Human

View/Edit Mouse

Interactions

TUBA1B has been shown to interact with PIK3R1.^[8] Antibodies against tubulin alpha 1b can be used as markers for microtubules and spindles.^[9]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000123416 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000023004 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Banerjee A (Jun 2002). "Increased levels of tyrosinated alpha-, beta(III)-, and beta(IV)-tubulin isotypes in paclitaxel-resistant MCF-7 breast cancer cells". Biochem Biophys Res Commun. 293 (1): 598–601. doi:10.1016/S0006-291X(02)00269-3. PMID 12054644.
^ Cowan NJ, Dobner PR, Fuchs EV, Cleveland DW (Jan 1984). "Expression of human alpha-tubulin genes: interspecies conservation of 3' untranslated regions". Mol Cell Biol. 3 (10): 1738–45. doi:10.1128/mcb.3.10.1738. PMC 370035. PMID 6646120.
^ "Entrez Gene: TUBA1B tubulin, alpha 1b".
^ Kapeller, R; Toker A; Cantley L C; Carpenter C L (Oct 1995). "Phosphoinositide 3-kinase binds constitutively to alpha/beta-tubulin and binds to gamma-tubulin in response to insulin". J. Biol. Chem. 270 (43). UNITED STATES: 25985–91. doi:10.1074/jbc.270.43.25985. ISSN 0021-9258. PMID 7592789.
^ "Anti-alpha Tubulin antibody [GT114] (GTX628802) | GeneTex".

Further reading

Venter JC (1993). "Identification of new human receptor and transporter genes by high throughput cDNA (EST) sequencing". J. Pharm. Pharmacol. 45. Suppl 1: 355–60. PMID 8098743.
Lopez-Fanarraga M, Avila J, Guasch A, et al. (2002). "Review: postchaperonin tubulin folding cofactors and their role in microtubule dynamics". J. Struct. Biol. 135 (2): 219–29. doi:10.1006/jsbi.2001.4386. PMID 11580271.
Kapeller R, Toker A, Cantley LC, Carpenter CL (1995). "Phosphoinositide 3-kinase binds constitutively to alpha/beta-tubulin and binds to gamma-tubulin in response to insulin". J. Biol. Chem. 270 (43): 25985–91. doi:10.1074/jbc.270.43.25985. PMID 7592789.
Alexandrova N, Niklinski J, Bliskovsky V, et al. (1995). "The N-terminal domain of c-Myc associates with alpha-tubulin and microtubules in vivo and in vitro". Mol. Cell. Biol. 15 (9): 5188–95. doi:10.1128/mcb.15.9.5188. PMC 230766. PMID 7651436.
Szasz J, Yaffe MB, Sternlicht H (1993). "Site-directed mutagenesis of alpha-tubulin. Reductive methylation studies of the Lys 394 region". Biophys. J. 64 (3): 792–802. Bibcode:1993BpJ....64..792S. doi:10.1016/S0006-3495(93)81440-1. PMC 1262393. PMID 8097117.
Baumann MH, Wisniewski T, Levy E, et al. (1996). "C-terminal fragments of alpha- and beta-tubulin form amyloid fibrils in vitro and associate with amyloid deposits of familial cerebral amyloid angiopathy, British type". Biochem. Biophys. Res. Commun. 219 (1): 238–42. doi:10.1006/bbrc.1996.0211. PMID 8619814.
Gress TM, Müller-Pillasch F, Geng M, et al. (1996). "A pancreatic cancer-specific expression profile". Oncogene. 13 (8): 1819–30. PMID 8895530.
Crépieux P, Kwon H, Leclerc N, et al. (1997). "I kappaB alpha physically interacts with a cytoskeleton-associated protein through its signal response domain". Mol. Cell. Biol. 17 (12): 7375–85. doi:10.1128/mcb.17.12.7375. PMC 232593. PMID 9372968.
Herreros L, Rodríguez-Fernandez JL, Brown MC, et al. (2000). "Paxillin localizes to the lymphocyte microtubule organizing center and associates with the microtubule cytoskeleton". J. Biol. Chem. 275 (34): 26436–40. doi:10.1074/jbc.M003970200. hdl:10261/135387. PMID 10840040.
Watts NR, Sackett DL, Ward RD, et al. (2000). "HIV-1 rev depolymerizes microtubules to form stable bilayered rings". J. Cell Biol. 150 (2): 349–60. doi:10.1083/jcb.150.2.349. PMC 2180222. PMID 10908577.
Takeoka A, Shimizu M, Horio T (2001). "Identification of an alpha-tubulin mutant of fission yeast from gamma-tubulin-interacting protein screening: genetic evidence for alpha-/gamma-tubulin interaction". J. Cell Sci. 113. Pt 24 (24): 4557–62. doi:10.1242/jcs.113.24.4557. PMID 11082048.
Germani A, Bruzzoni-Giovanelli H, Fellous A, et al. (2001). "SIAH-1 interacts with alpha-tubulin and degrades the kinesin Kid by the proteasome pathway during mitosis". Oncogene. 19 (52): 5997–6006. doi:10.1038/sj.onc.1204002. PMID 11146551.
Yokota S, Yanagi H, Yura T, Kubota H (2001). "Cytosolic chaperonin-containing t-complex polypeptide 1 changes the content of a particular subunit species concomitant with substrate binding and folding activities during the cell cycle". Eur. J. Biochem. 268 (17): 4664–73. doi:10.1046/j.1432-1327.2001.02393.x. PMID 11532003.
Rommelaere H, De Neve M, Neirynck K, et al. (2001). "Prefoldin recognition motifs in the nonhomologous proteins of the actin and tubulin families". J. Biol. Chem. 276 (44): 41023–8. doi:10.1074/jbc.M106591200. PMID 11535601.
Klein C, Kramer EM, Cardine AM, et al. (2002). "Process outgrowth of oligodendrocytes is promoted by interaction of fyn kinase with the cytoskeletal protein tau". J. Neurosci. 22 (3): 698–707. doi:10.1523/JNEUROSCI.22-03-00698.2002. PMC 6758498. PMID 11826099.
Saugstad JA, Yang S, Pohl J, et al. (2002). "Interaction between metabotropic glutamate receptor 7 and alpha tubulin". J. Neurochem. 80 (6): 980–8. doi:10.1046/j.0022-3042.2002.00778.x. PMC 2925652. PMID 11953448.

External links

TUBA1B human gene location in the UCSC Genome Browser.
TUBA1B human gene details in the UCSC Genome Browser.

This article on a gene on human chromosome 12 is a stub. You can help Wikipedia by expanding it.

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