TUBE1

Tubulin, epsilon 1 is a protein in humans that is encoded by the TUBE1 gene. This gene encodes a member of the tubulin superfamily. This protein localizes to the centriolar sub-distal appendages that are associated with the older of the two centrioles after centrosome duplication. This protein plays a central role in organization of the microtubules during centriole duplication

TUBE1
Identifiers
Aliases	TUBE1, TUBE, dJ142L7.2, tubulin epsilon 1
External IDs	OMIM: 607345; MGI: 1919174; HomoloGene: 17762; GeneCards: TUBE1; OMA:TUBE1 - orthologs
Gene location (Human) Chr. Chromosome 6 (human) Band 6q21 Start 112,070,663 bp End 112,087,529 bp
Gene location (Mouse) Chr. Chromosome 10 (mouse) Band 10|10 B1 Start 39,133,976 bp End 39,152,542 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in right hemisphere of cerebellum oocyte secondary oocyte pancreatic epithelial cell Achilles tendon body of uterus right lobe of liver cardiac muscle tissue of right atrium right auricle C1 segment Top expressed in thymus secondary oocyte medullary collecting duct hand neural layer of retina primary oocyte primitive streak zygote renal corpuscle genital tubercle More reference expression data BioGPS n/a
Gene ontology Molecular function nucleotide binding GTP binding structural constituent of cytoskeleton GTPase activity Cellular component cytoplasm microtubule pericentriolar material cytoskeleton microtubule organizing center Biological process centrosome cycle microtubule-based process microtubule cytoskeleton organization mitotic cell cycle Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 51175 71924 Ensembl ENSG00000074935 ENSMUSG00000019845 UniProt Q9UJT0 Q9D6T1 RefSeq (mRNA) NM_016262 NM_028006 RefSeq (protein) NP_057346 NP_082282 Location (UCSC) Chr 6: 112.07 – 112.09 Mb Chr 10: 39.13 – 39.15 Mb PubMed search
Wikidata
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Further reading

• Chang P, Giddings TH, Winey M, Stearns T (January 2003). "Epsilon-tubulin is required for centriole duplication and microtubule organization". Nature Cell Biology. 5 (1): 71–6. doi:10.1038/ncb900. PMID 12510196. S2CID 1318660.
• Zanic M, Stear JH, Hyman AA, Howard J (October 2009). May RC (ed.). "EB1 recognizes the nucleotide state of tubulin in the microtubule lattice". PLOS ONE. 4 (10): e7585. Bibcode:2009PLoSO...4.7585Z. doi:10.1371/journal.pone.0007585. PMC 2761489. PMID 19851462.
• Chang P, Stearns T (January 2000). "Delta-tubulin and epsilon-tubulin: two new human centrosomal tubulins reveal new aspects of centrosome structure and function". Nature Cell Biology. 2 (1): 30–5. doi:10.1038/71350. PMID 10620804. S2CID 23500269.