Twinfilin-1 is a protein that in humans is encoded by the TWF1 gene.[5][6] This gene encodes twinfilin, an actin monomer-binding protein conserved from yeast to mammals. Studies of the mouse counterpart suggest that this protein may be an actin monomer-binding protein, and its localization to cortical G-actin-rich structures may be regulated by the small GTPase RAC1.[6]

TWF1
Identifiers
AliasesTWF1, A6, PTK9, twinfilin actin binding protein 1
External IDsOMIM: 610932; MGI: 1100520; HomoloGene: 48140; GeneCards: TWF1; OMA:TWF1 - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001242397
NM_002822
NM_198974

NM_008971

RefSeq (protein)

NP_001229326
NP_002813

NP_032997
NP_001389738
NP_001389739

Location (UCSC)Chr 12: 43.79 – 43.81 MbChr 15: 94.48 – 94.49 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

References

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  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000151239Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000022451Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Beeler JF, LaRochelle WJ, Chedid M, Tronick SR, Aaronson SA (February 1994). "Prokaryotic expression cloning of a novel human tyrosine kinase". Mol. Cell. Biol. 14 (2): 982–8. doi:10.1128/mcb.14.2.982. PMC 358453. PMID 7507208.
  6. ^ a b "Entrez Gene: TWF1 twinfilin, actin-binding protein, homolog 1 (Drosophila)".

Further reading

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