Twisted gastrulation protein homolog 1 is a protein that in humans is encoded by the TWSG1 gene.[5][6] The protein is a binding protein for bone morphogenetic proteins, similar to Chordin.[7] The Twisted gastrulation gene is expressed in the extraembryonic tissues during organogenesis, and in certain adult tissues such as the lymph nodes, kidneys, liver, and lungs.[8]

TWSG1
Identifiers
AliasesTWSG1, TSG, twisted gastrulation BMP signaling modulator 1
External IDsOMIM: 605049; MGI: 2137520; HomoloGene: 10774; GeneCards: TWSG1; OMA:TWSG1 - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_020648

NM_023053

RefSeq (protein)

NP_065699

NP_075540

Location (UCSC)Chr 18: 9.33 – 9.4 MbChr 17: 66.23 – 66.26 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

References

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  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000128791Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000024098Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Scott IC, Blitz IL, Pappano WN, Maas SA, Cho KW, Greenspan DS (Mar 2001). "Homologues of Twisted gastrulation are extracellular cofactors in antagonism of BMP signalling". Nature. 410 (6827): 475–8. doi:10.1038/35068572. PMID 11260715. S2CID 4392365.
  6. ^ "Entrez Gene: TWSG1 twisted gastrulation homolog 1 (Drosophila)".
  7. ^ Oelgeschläger M, Larraín J, Geissert D, De Robertis EM (2000). "The evolutionarily conserved BMP-binding protein Twisted gastrulation promotes BMP signalling". Nature. 405 (6788): 757–63. Bibcode:2000Natur.405..757O. doi:10.1038/35015500. PMC 2292104. PMID 10866189.
  8. ^ Graf D, Timmons PM, Hitchins M, Episkopou V, Moore G, Ito T, Fujiyama A, Fisher AG, Merkenschlager M (July 2001). "Evolutionary conservation, developmental expression, and genomic mapping of mammalian Twisted gastrulation". Mammalian Genome. 12 (7): 554–560. doi:10.1007/s0033501-0005-x. ISSN 0938-8990. PMID 11420619. S2CID 36371559. Retrieved 6 March 2023.

Further reading

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