Thioredoxin reductase 1, cytoplasmic is an enzyme that in humans is encoded by the TXNRD1 gene.[5]

TXNRD1
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesTXNRD1, GRIM-12, TR, TR1, TRXR1, TXNR, thioredoxin reductase 1
External IDsOMIM: 601112; MGI: 1354175; HomoloGene: 55733; GeneCards: TXNRD1; OMA:TXNRD1 - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001042513
NM_001042514
NM_001042523
NM_015762

RefSeq (protein)

NP_001035978
NP_001035979
NP_001035988
NP_056577

Location (UCSC)Chr 12: 104.22 – 104.35 MbChr 10: 82.67 – 82.73 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

This gene encodes a member of the family of pyridine nucleotide oxidoreductases. This protein reduces thioredoxins as well as other substrates, and plays a role in selenium metabolism and protection against oxidative stress. The functional enzyme is thought to be a homodimer which uses FAD as a cofactor. Each subunit contains a selenocysteine (Sec) residue which is required for catalytic activity. The selenocysteine is encoded by the UGA codon that normally signals translation termination. The 3' UTR of selenocysteine-containing genes have a common stem-loop structure, the sec insertion sequence (SECIS), that is necessary for the recognition of UGA as a Sec codon rather than as a stop signal. Alternative splicing results in several transcript variants encoding the same or different isoforms.[6]

See also

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References

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  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000198431Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000020250Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Gasdaska PY, Gasdaska JR, Cochran S, Powis G (Nov 1995). "Cloning and sequencing of a human thioredoxin reductase". FEBS Lett. 373 (1): 5–9. doi:10.1016/0014-5793(95)01003-W. PMID 7589432. S2CID 735874.
  6. ^ "Entrez Gene: TXNRD1 thioredoxin reductase 1".

This article incorporates text from the United States National Library of Medicine, which is in the public domain.