TYSND1

Trypsin domain containing 1 is a protein that in humans is encoded by the TYSND1 gene.

TYSND1
Identifiers
Aliases	TYSND1, NET41, trypsin domain containing 1, trypsin like peroxisomal matrix peptidase 1
External IDs	OMIM: 611017; MGI: 1919017; HomoloGene: 87946; GeneCards: TYSND1; OMA:TYSND1 - orthologs
Gene location (Human) Chr. Chromosome 10 (human) Band 10q22.1 Start 70,137,981 bp End 70,146,700 bp
Gene location (Mouse) Chr. Chromosome 10 (mouse) Band 10|10 B4 Start 61,531,293 bp End 61,538,552 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in left testis right testis skin of abdomen skin of leg mucosa of transverse colon granulocyte right adrenal gland right lobe of liver right lobe of thyroid gland left adrenal gland Top expressed in right kidney proximal tubule left lobe of liver brown adipose tissue internal carotid artery human kidney adrenal gland external carotid artery ankle joint duodenum More reference expression data BioGPS n/a
Gene ontology Molecular function protease binding peptidase activity serine-type peptidase activity hydrolase activity identical protein binding serine-type endopeptidase activity Cellular component peroxisome membrane peroxisomal matrix cytosol Biological process protein processing regulation of fatty acid beta-oxidation protein homooligomerization proteolysis protein targeting to peroxisome Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 219743 71767 Ensembl ENSG00000156521 ENSMUSG00000020087 UniProt Q2T9J0 Q9DBA6 RefSeq (mRNA) NM_001040273 NM_173555 NM_001272090 NM_001272091 NM_001272092 NM_027912 RefSeq (protein) NP_001035363 NP_775826 NP_001259019 NP_001259020 NP_001259021 NP_082188 Location (UCSC) Chr 10: 70.14 – 70.15 Mb Chr 10: 61.53 – 61.54 Mb PubMed search
Wikidata
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Function

This gene encodes a protease that removes the N-terminal peroxisomal targeting signal (PTS2) from proteins produced in the cytosol, thereby facilitating their import into the peroxisome.

The encoded protein is also capable of cleaving several proteins targeted to peroxisomes through the C-terminal peroxisomal targeting signal (PTS1). The full-length protein undergoes self-cleavage to produce shorter, potentially inactive fragments. Alternative splicing results in multiple transcript variants for this gene.

Further reading

• Grupe A, Li Y, Rowland C, Nowotny P, Hinrichs AL, Smemo S, Kauwe JS, Maxwell TJ, Cherny S, Doil L, Tacey K, van Luchene R, Myers A, Wavrant-De Vrièze F, Kaleem M, Hollingworth P, Jehu L, Foy C, Archer N, Hamilton G, Holmans P, Morris CM, Catanese J, Sninsky J, White TJ, Powell J, Hardy J, O'Donovan M, Lovestone S, Jones L, Morris JC, Thal L, Owen M, Williams J, Goate A (2006). "A scan of chromosome 10 identifies a novel locus showing strong association with late-onset Alzheimer disease". Am. J. Hum. Genet. 78 (1): 78–88. doi:10.1086/498851. PMC 1380225. PMID 16385451.
• Kurochkin IV, Mizuno Y, Konagaya A, Sakaki Y, Schönbach C, Okazaki Y (2007). "Novel peroxisomal protease Tysnd1 processes PTS1- and PTS2-containing enzymes involved in beta-oxidation of fatty acids". EMBO J. 26 (3): 835–45. doi:10.1038/sj.emboj.7601525. PMC 1794383. PMID 17255948.
• Rose JE, Behm FM, Drgon T, Johnson C, Uhl GR (2010). "Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score". Mol. Med. 16 (7–8): 247–53. doi:10.2119/molmed.2009.00159. PMC 2896464. PMID 20379614.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.