Trypsin domain containing 1 is a protein that in humans is encoded by the TYSND1 gene. [5]

TYSND1
Identifiers
AliasesTYSND1, NET41, trypsin domain containing 1, trypsin like peroxisomal matrix peptidase 1
External IDsOMIM: 611017; MGI: 1919017; HomoloGene: 87946; GeneCards: TYSND1; OMA:TYSND1 - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001040273
NM_173555

NM_001272090
NM_001272091
NM_001272092
NM_027912

RefSeq (protein)

NP_001035363
NP_775826

NP_001259019
NP_001259020
NP_001259021
NP_082188

Location (UCSC)Chr 10: 70.14 – 70.15 MbChr 10: 61.53 – 61.54 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Function

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This gene encodes a protease that removes the N-terminal peroxisomal targeting signal (PTS2) from proteins produced in the cytosol, thereby facilitating their import into the peroxisome.

The encoded protein is also capable of cleaving several proteins targeted to peroxisomes through the C-terminal peroxisomal targeting signal (PTS1). The full-length protein undergoes self-cleavage to produce shorter, potentially inactive fragments. Alternative splicing results in multiple transcript variants for this gene.

References

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  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000156521Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000020087Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ "Entrez Gene: Trypsin domain containing 1". Retrieved 2017-10-02.

Further reading

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This article incorporates text from the United States National Library of Medicine, which is in the public domain.