Talk:ALDH2

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Article split?

Latest comment: 11 months ago4 comments3 people in discussion

@De la Marck: By consensus, the vast majority of Gene Wiki articles are about both the gene and the protein that is encoded by the gene. The properties of genes and proteins are so interrelated, it make senses to include both in the same article. The {{Infobox gene}} templates by design contain external links to information about the protein and gene and for consistency, we have merged a number of separate gene and protein articles in the past. Hence I propose that ALDH2 gene be merged back into this article. Boghog (talk) 05:46, 15 October 2016 (UTC)Reply

This one was so large and hairy that I consider it didn't quite fit the rule. Notice how in the previous version the enzyme and its encoding gene were illogically confused together? Putting them back together one would want to comb it out considerably. Also, most comparable articles are primarily about the enzyme/protein, and titled for such, but this was - albeit confusedly - more directly associated with the gene. Le Sanglier des Ardennes (talk) 06:18, 15 October 2016 (UTC)Reply

OK, I now see that the lead sentence in the pre-split version was not optimal. Concering the lead sentence in Gene Wiki articles, as discussed here and here, we have tried to make clear that these articles are not only about the human gene/protein, but also orthologs that exist in other species. The wording that was reached through consensus is perhaps a little awkward, but it is both accurate and concise:

<recommended UniProt name> is a protein that in humans is encoded by the <approved HUGO gene symbol> gene.

The "that" in the above sentence is non-limiting implying that the protein (and gene) exists in other species besides human. Would changing the the lead sentence in this article to the following:

Aldehyde dehydrogenase, mitochondria is a protein that in humans is encoded by the ALDH2 gene.

reduce the confusion? Boghog (talk) 06:59, 15 October 2016 (UTC)Reply

There’s some unfortunate remnants from pre-split that needs to be cleaned up, but bedtime’s not allowing me to do it right now. Specifically, I believe the lede is talking about isozymes too much when something as simple as "this is one of many, this one specifically lives in the micochondria and is good at processing ethanal" is enough — maybe just move "Isoforms" section to the lede. Also, "isoforms" means way too many things from splice variant to paralogs to, duh, isozymes for me to trust that word.

I also don’t like relying too heavily on entrez summaries. Artoria 2e5 🌉 14:43, 9 November 2023 (UTC)Reply

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