Talk:Acetylcholinesterase inhibitor

Antidotes?

Why doesn't the article mention pralidoxime, diezepan, or norepinephrine as potential remedies for the effects of acetylcholinesterase inhibitors? - 2-16 15:03, 30 May 2007 (UTC)

Pralidoxime and similar oxime acetylcholinesterase reactivators (the "golden standard" of these beeing now asoxime) are useful only in serious life-threating intoxications by some organophosphates (e.g. parathion, or NA's sarin or VX); they are less to not at all useful in soman (GD) intoxications, and actually contraindicated in carbamate intoxications (by carbaryl, carbofurane, bendiocarb or neostigmine), because, upon decarbamoylation of the blocked enzyme, oxime carbamates, that are more toxic than the actual parent noxae (i.e. the carabamate poison) forms; by "diezepan", I assume, you ment diazepam, which is indicated for symptomatic reversal of muscle fasciculations and seizures, as well as for calming the poisoned victim down and improve outcome in severe NCWA intoxications; noradrenaline is even of lower relevance, since it is only a symptomatic treatment of circulatory collapse, which is not a core symptom of AChEI intoxication; the only real "advisable" antidote for all AChEIs is atropine, given by i.v. titration. It is the only agent, that does help in all AChEI intoxications (though the most severe intoxications are often lethal despite high-dose atropine), regardless of their severity or casual noxis, i.e. one could not make a manifest AChEI intoxication worse by administration of atropine, as opposed to e.g. oximes. However, this article deals not so much with AChEI toxicology, it's only a brief summary of mechanisms and agents; the respective articles nerve agent and insecticide provide specific information about causal and symptomatic treatment of intoxications.--84.163.96.19 20:25, 29 September 2007 (UTC)

Mechanism

I was reading http://www.guardian.co.uk/science/2009/sep/20/neuroenhancers-us-brain-power-drugs and it mentioned cholinesterase inhibitors as a coming big thing in nootropics, but I was a little puzzled.

Choline supplements of various stripes have been available for a very long time, and I understood that they worked by encouraging choline->acetylcholine, and acetylcholinesterase works by destroying acetylcholine; so wouldn't the end-goal of choline supplementation and acetylcholinesterase inhibition be the same: a rise in acetylcholine? Why then the interest? --129.49.7.125 (talk) 21:33, 1 October 2009 (UTC)

Review

Interesting review [1] --Doc James (talk · contribs · email) 15:37, 30 April 2011 (UTC)

Link broken? (access attempt failed April 28, 2013)

Ocdnctx (talk) 18:31, 28 April 2013 (UTC)

Supplements inhibiting Acetylcholinesterase

Supplements inhibiting Acetylcholinesterase include

Bacopa

Acetyl-L-Carnitine

Such supplements, as well as Huperzine etc., share many of the side effects of pharmaceutical acetylcholinesterase inhibitors.

Ocdnctx (talk) 18:29, 28 April 2013 (UTC)

effects

I think it is worth having an effects section of this article. The side effects covers unintended consequences, possibly reflecting a a smaller or chronic dose. And uses section is the practical realization of intended effects. But the direct consequences of intended use are not listed here. This would be the consequences to a prey organism of a spider bite (paralysis) or the use of a chemical weapon. Dbsseven (talk) 19:58, 14 March 2018 (UTC)

partial inhibition?

Are there any examples of acetylcholinesterase partial inhibitors known?

(An enzyme partial inhibitor is a substance that reduces the speed at which the enzyme catalyzes the reaction of its substrate, but it does not disable the enzyme completely even at high concentration. This means, an ACHE partial inhibitor would slow down cholinergic transmission, but not as extremely as a complete inhibitor.) --79.240.205.49 (talk) 00:30, 9 August 2018 (UTC)