Talk:Acinetobacter baumannii
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Removal of LPS passage
editI am responding here to Garnhami's question to me on my Talk page about the removal of this passage [1]:
Lipopolysaccharide isolated from A. baumannii demonstrated the biological activity similar to that of classical LPS from Escherichia coli, consistent with the presence of highly acylated lipid A in both strains. Interestingly, the former was a slightly weaker activator than the latter. This observation can be explained by the difference between the average length of acyl groups in the most abundant hexa- and heptaacylated forms of A. baumannii lipid A compared to E. coli lipid A. In A. baumannii lipid A, most of the acyl groups have 12 carbon atoms and only one or two have 14 carbon atoms, whereas in E. coli lipid A most of the acyl chains are C14 derivatives. Such LPS with high biological activity would be able to induce septic shock in susceptible patients, but at the same time this type of LPS provide proper recognition by TLR4/MD-2 complex of host innate immune system as compared to LPS with the low biological activity, as for example in the case of Pseudomonas aeruginosa.[1]
References
- ^ Korneev, K; Arbatsky, N; Molinaro, A; Palmigiano, A; Shaikhutdinova, R; Shneider, M; Pier, G; Kondakova, A; Sviriaeva, E; Sturiale, L; Garozzo, D; Kruglov, A; Nedospasov, S; Drutskaya, M; Knirel, Y; Kuprash, D (2015). "Structural Relationship of the Lipid A Acyl Groups to Activation of Murine Toll-Like Receptor 4 by Lipopolysaccharides from Pathogenic Strains of Burkholderia mallei, Acinetobacter baumannii, and Pseudomonas aeruginosa". Frontiers in immunology. 6: 595. doi:10.3389/fimmu.2015.00595. PMID 26635809.
{{cite journal}}: CS1 maint: unflagged free DOI (link)
Note that this passage had been added to the section "Virulence factors and determinants." There are several issues with the cited study, but the main one is that a high-quality review article (secondary source) should be cited. The reference that the IP provided is a primary source. See WP:Undue weight. I have not found a single review article that cites this paper in describing the role of LPS in virulence. CatPath (talk) 19:47, 29 April 2017 (UTC)
How the hospital pathogen Acinetobacter baumannii quickly adapts to new environmental conditions
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