Talk:Aconitine

SMILES Formula

Should anyone need it, the full formula, with all the chirality hints, is COC[C@]12CN(C)[C@@H]3[C@H]4[C@H](OC)C1[C@@]3([C@H](C[C@H]2O)OC)[C@@H]5C[C@]6(O)[C@@H](OC)[C@H](O)[C@@]4(OC(C)=O)[C@H]5C6OC(=O)c7ccccc7

Stripping out the chirality information, you get the still horrible COCC12CN(C)C3C4C(OC)C1C3(C(CC2O)OC)C5CC6(O)C(OC)C(O)C4(OC(C)=O)C5C6OC(=O)c7ccccc7 —The preceding unsigned comment was added by 71.41.210.146 (talk) 05:19, 28 April 2007 (UTC).

Moved from article

I've moved to following comment from the article to here. -- Ed (Edgar181) 11:44, 2 February 2008 (UTC)

AS FAR AS I KNOW BELLADONNA, HENBANE ETC. WOULD WORK AS ANTIDOTE'S AS IT WAS BY MIXING ACONITE WITH THEM THAT MEDIEVAL MIDWIVES WERE ABLE TO USE IT TO INDUCE TWILIGHT SLEEP WITHOUT POISONING PEOPLE

Toxicity in human

"One to ten milligrams per kilogram body weight are said to be deadly to humans."

Ludewig; Regenthal et al. (2007) do list 1.5 - 6 mg aconitine nitrate per os as the lethal dose for a man. This is coherent with figures of other authors, including the classical work of Louis Lewin, Gifte und Vergiftungen (1928), which is considered by many toxicologists as one of the fundamental works of modern toxicology. I myself was teached in lectures, that aconitine is the deadliest alcaloid found in european plants, with dosis leth. singula in order of 5 - 10 mg p.o. I'll change therefore the figure given in the article.--84.163.126.131 (talk) 18:20, 12 February 2008 (UTC)

While certainly, 1 – 10 mg/kg BM p.o. (e.g., 75 - 750 mg for a person of BM = 75 kg) would be lethal, this figure was misleading, because it didn't illustrate the truly high toxicity of aconitine in human. ;) --84.163.126.131 (talk) 18:35, 12 February 2008 (UTC)

By the way, does anyone know the symptoms of aconite poisoning from a flesh wound? (I have an old Chinese account which I am translating describing the effects of the use of poisoned arrows. I think aconite was the most likely poison used - but knowing the symptoms would possibly help make the case for aconite stronger - or weaker). Many thanks, John Hill (talk) 04:31, 18 May 2009 (UTC)

11 March 2017 -- Does this article adequately emphasize that the foliage is substantially toxic, and that toxicity is not restricted to the root? If not, please edit. http://www.thepoisongarden.co.uk/atoz/aconitum_napellus.htm — Preceding unsigned comment added by Dpwkbw (talk • contribs) 17:40, 11 March 2017 (UTC)

Research for use as a medicine?

I know this product is danger, but botox became a medicine.Is tehre any research for use as a medicine, in weak doses?Agre22 (talk) 03:58, 18 May 2009 (UTC)agre22

Aconite is very popular in Chinese herbal medicine, and is called Fuzi. Surprising there is not a wikipedia article mentioning Fuzi. It may be even one of the most important medicines. Recently, two people were poisoned from drinking improperly prepared Fuzi in San Francisco, and one of them died. (Search news for "aconite poisoning"). This information could well be added to this article.Jimhoward72 (talk) 03:42, 9 May 2017 (UTC)

use in whaling

I just found this. Someone can follow up if there is interest. In Flotasametrics and the Floating World:... by Curtis Ebesmeyer and Eric Scigliano. ISBN 9780-006-155841-2, 2009 HarperCollins, there is a section on Whaling in Further Reading, p 266. The authors say:

Aleuts in skin baidarkas hunted whales with poisoned lances. Heizer, R, F, 1938. "Aconite Poison Whaling in Asia and America: An Aleutian Transfer to the New World." Bulletin of American Ethnology 133:417-68. Heizer, Robert F., 1938. "Aconite Arrow Poison in the Old and New World." Journal of the Washington Academy of Sciences 28 (8):358-64.

--AJim (talk) 15:32, 1 July 2009 (UTC)

queen of poisons

This is widely known as the "queen of poisons" can someone add it please to here through a redirect. —Preceding unsigned comment added by 78.105.34.66 (talk) 14:04, 10 February 2010 (UTC)

this is not known as "queen of poisons" that was just a blurb stated on the Showtime series "Dexter". This is not known as the queen of all poisons, it was only a fictional statement by the character Dexter on a fictional tv show — Preceding unsigned comment added by 75.90.34.48 (talk) 18:10, 6 November 2012 (UTC)

In the TV Show "Dexter", an episode named "Do the Wrong Thing" first aired on Sunday, November 4, 2012, parts of this article, including the photo for Aconitum variegatum, were actually used in the show. The article heading was "Aconite". The name of the website was "Web Encyclopedia" at the fictitious URL of "https://en.webencyclopedia.web/article/Aconite". The actual phrase used by Dexter was "The queen of all poisons". Gatortpk (talk) 00:39, 17 November 2012 (UTC)

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Why is there a picture of "a six year-old boy with Down Syndrome on his first day of school" for this page?

Why in the world is there a picture of "a six year-old boy with Down Syndrome on his first day of school" for Aconitine ?

Please explain and/or change this, thanks

Grinx 22 (talk) 12:15, 30 October 2019 (UTC)