Talk:Aequorin

Article cleanup

I had tried to clean up the article, make it more general and explicative, and cite properly. Addressing some of comments below, green-glowing pigs (and many other animals) are expressing GFP, not aequorin, so it should be in that page and not be discussed here. I have seen no evidence related to calcium balance and aequorin by any reputed medical journal, so that should remain out of the page until verified facts are in. Wrfrancis (talk) 00:28, 14 March 2014 (UTC)

Treating neurodegenerative diseases

Aequorin, as a calcium binder, could be a substitute for when the brain loses the ability to maintain a healthy balance of calcium.[1]69.6.162.160 01:43, 28 October 2006 (UTC)Brian Pearson

Just have a look

Taiwan breeds green-glowing pigs[2]... "To create them, DNA from jellyfish was added to about 265 pig embryos which were implanted in eight different sows." Aequorea victoria [3], also called the crystal jelly, is a bioluminescent jellyfish —Preceding unsigned comment added by 77.190.65.205 (talk) 22:31, 14 January 2008 (UTC)

Sold as a Anti-Aging Pill

It might be worth mentioning that Aequorin is also sold as a "Anti-Aging" pill as Prevagen. http://www.prevagen.com/ —Preceding unsigned comment added by 99.240.159.98 (talk) 15:29, 3 May 2008 (UTC)

NO it is not. The product to which you are referring is apoaequorin not aequorinUser:Pedant (talk) 20:43, 16 June 2010 (UTC)

I'm curious about this too. It is being sold for prevention of memory loss/brain cell protection.

link removed

(I buy vitamins from this place. I'm not trying to drive traffic to their site, it is just where I found out about the product.) —Preceding unsigned comment added by 24.21.136.81 (talk) 23:51, 4 October 2009 (UTC)

(link removed, there are multiple sources for this supplement, wikipedia is not a link repository -- not even on talk pages.)

User:Pedant (talk) 20:43, 16 June 2010 (UTC)

I noticed a link from the prevagen site "More information on Apoaequorin" links here, despite the spelling differences noted above. Are Aequorin and Apoaequorin synonyms? Can this similarity or distinction be addressed or reconciled in this article? I recognize that Wikipedia has no responsibility for external links, but I am certainly curious to learn more about the effectiveness of this protein (or that protein if they are in fact different) as an anti-aging solution. I will risk a scolding to mention the link I am referring to is from the page at: https://www.prevagen.com/about-improve-memory/apoaequorin/ Thanks for this consideration --Lbeaumont (talk) 12:52, 1 February 2016 (UTC)

I posed this question to a contact on the prevagen site. Here is his response:

aequorin and apoaequorin are the same except aequorin also includes coelenterazine, which causes the molecule to glow when binding calcium, apoaequorin just binds the calcium with no glowing (luminescence).

Here is a more technical description of the above…

Aequorin is a holoprotein composed of two distinct units, the apoprotein that is called apoaequorin, which has an approximate molecular weight of 21 kDa, and the prosthetic group coelenterazine, the luciferin. This is to say, apoaequorin is the enzyme produced in the photocytes of the animal, and coelenterazine is the substrate whose oxidation the enzyme catalyzes. When coelenterazine is bound, it is called aequorin. Notably, the protein contains three EF hand motifs that function as binding sites for Ca2+ ions. The protein is a member of the superfamily of the calcium-binding proteins of which there are some 66 subfamilies.

Perhaps we can include this clarification in the article, and direct both aequorin and apoaequorin to this site. (his original response included wiki-links and footnotes. I can provide these if they are helpful) Thanks! --Lbeaumont (talk) 17:20, 1 February 2016 (UTC)

Duh - I now see that this is the first paragraph as it already appears in the "structure" section of the article. Therefore I suggest linking apoaequorin to this article, and discussing its use in an Anti-aging pill. Thanks! --Lbeaumont (talk) 17:24, 1 February 2016 (UTC)

New Comment: The article on Aequorin is caught in a bit of a scandal. An article on the much more important Apoaequorin is substantively missing from Wikipedia. Further, searches for Apoaequorin and the drug trade name Prevagen on Google search engines lead to Aequorin as a search result. Apoaequorin is of enormous social importance right now because it is in a 'vitamin supplement' being being marketed aggressively as Prevagen on american television screens as a memory enhancing 'drug-like product.' It is simultaneously under criticism by the FDA as having entirely fraudulent efficacy claims (because the large Apoaequorin molecule is destroyed in the GI tract and otherwise could not cross the blood-brain barrier), having dangerous side effects, and of not even qualifying as being a supplement rather than drug because it is being synthetically created by Quincy Bioscience. The scandalous part is that an Apoaequorin article is missing from Wikipedia, indicating by logical deduction that such an article is being somehow suppressed and/or that Wikipedia management may feel the desire to avoid a possible lawsuit against them from Quincy Bioscience LLC whose recent meteoric financial 'success' hinges almost entirely on this one product. But the importance of an article on this right now, socially, is enormous, so it brings up legitimate questions I think about Wikipedia's position of principle on issues such as this. (talk) 11:53, 13 August 2016 (UTC)

External links modified

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"Prevagen" may now be Notable - and worthy of an Article?

Seems "Prevagen" may now be Notable - and worthy of an Article - or, at least, a Redirect? See quoted text below:

Copied from the Aequorin article

Apoaequorin is an ingredient in "Prevagen", which is marketed by Quincy Bioscience as a memory supplement. The US Federal Trade Commission (FTC) has charged the maker of false advertising, because they claim marketing statements are not supported by scientific studies. Quincy says it will fight the charges.

References

Comments Welcome - in any case - Enjoy! :) Drbogdan (talk) 00:40, 8 July 2017 (UTC)