Talk:Agouti-related peptide

Wiki Education Foundation-supported course assignment

This article was the subject of a Wiki Education Foundation-supported course assignment, between 19 January 2021 and 16 April 2021. Further details are available on the course page. Student editor(s): Neuron2000.

Above undated message substituted from Template:Dashboard.wikiedu.org assignment by PrimeBOT (talk) 13:38, 16 January 2022 (UTC)

Comment

Why is it named after a South-American rodent?!

No idea -- what's an Agouti anyway? -- The Anome 15:29, 11 March 2006 (UTC)

Agouti is a protein found in the epidermis that binds to MC1R producing a yellow/tan fur color. Agouti Related protein (Ag R P) is structurally similar protein important in metabolism regulation that is found in the brain. AgRP is AgrP. peptide and protein are synonymous. i.e. these should be merged.

Agouti protein was named after the South-American rodent because it produces coat color similar to this rodent. In mice, agouti protein is transiently synthesized in the skin to give different coat colors during development. Certain mice however possess a mutation in the Agouti gene inducing a prolong and ectopic expression of agouti including in the brain. These animals develop obesity and diabetes by blocking melanocortin 4 receptors (Mc4r).

Planned edits

Add updated discoveries on the role of AGRP neurons in hunger circuitry and the details on: when they are active, what they signal with, and what hormones affect them. Neuron2000 (talk) 16:30, 2 April 2021 (UTC)Neuron2000 — Preceding unsigned comment added by Neuron2000 (talk • contribs) 16:28, 2 April 2021 (UTC)