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editAbnormal AFP values
editThe AFP value of 500ng/ml seems very high, according to http://emedicine.medscape.com/article/454477-workup#a0719 a level of > 9 ng/ml is considered abnormal in context of testicular cancer? — Preceding unsigned comment added by 82.161.33.118 (talk) 22:11, 20 March 2013 (UTC)
RECAF
editRECAF, cell membrane receptor for AFP, may be useful as a tumor marker itself: http://www.devicelink.com/ivdt/archive/05/06/004.html and newer: https://www.novapublishers.com/catalog/product_info.php?products_id=58825
Need to look into this. Una Smith 04:11, 12 June 2007 (UTC)
The AFP receptor (AFPR) is an oncofetal antigen which unlike AFP is re-expressed by most types of cancer: https://www.novapublishers.com/catalog/product_info.php?products_id=58825. AFPR is not a universal tumor marker: https://www.ncbi.nlm.nih.gov/pubmed/29211355. In addition to embryotic and cancer cells AFPR is expressed by myeloid-derived suppressor cells (MDSCs): https://www.ncbi.nlm.nih.gov/pubmed/28956104. MDSC can be targeted through AFPR: https://doi.org/10.4155/fsoa-2018-0029 and be used for the treatment of autoimmune diseases and cancer: https://www.ncbi.nlm.nih.gov/pubmed/29216804 https://doi.org/10.4155/tde-2018-0068. — Preceding unsigned comment added by Aimpila (talk • contribs) 18:16, 8 January 2019 (UTC)
AFPep treats breast cancer
editSciencenews magazine, vol 168, p307, 11/12/05, reports that James Bennett of the Albany (N.Y.) Medical College and colleagues have synthisized a ring-shape peptide called AFPep. This checks the progress of breast cancers in mice as well as Tamoxifen, and when given with Tamoxifen an even greater effect is observed.
- Is this a major trend in research? Are there other studies duplicating this result? When are phase I trials expected? At this juncture I'm not sure if this should be included in this article just yet. JFW | T@lk 19:56, 24 November 2005 (UTC)
- I presume we're talking about DeFreest LA, Mesfin FB, Joseph L, McLeod DJ, Stallmer A, Reddy S, Balulad SS, Jacobson HI, Andersen TT, Bennett JA. Synthetic peptide derived from alpha-fetoprotein inhibits growth of human breast cancer: investigation of the pharmacophore and synthesis optimization. J Pept Res 2004;63:409-19. PMID 15140158. JFW | T@lk 19:58, 24 November 2005 (UTC)
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editmerge
editPossible merge with AFP screening?
Yep, that's what i did. The part copied from there may be referring more to the triple test, than to afp alone. I have to establish this before i change it too much. Tristanb 01:04, 5 August 2005 (UTC)
The link to the Chinese page seems to be a dead-end. Una Smith 17:16, 9 April 2007 (UTC)
You'll need an account with zh.wikipedia to create the new page. My en.wikipedia account cannot access it too. Since you might have problem with Chinese, do you want me help you create an account there? Samantha 02:40, 10 April 2007 (UTC)