Talk:Amiloride

Distal tubules???

I'm pretty sure amiloride works on the collecting tubule, not on the distal tubule. I'll check on this and make corrections if I'm right. —Preceding unsigned comment added by 201.130.132.118 (talk) 03:52, 26 March 2008 (UTC)

It woks on both segments, although most importantly in the principal cells of the collecting tubule, same as aldosterone.Lui1014 (talk) 04:40, 26 March 2008 (UTC)

I gotta second the first comment here, I'm pretty sure there aren't any ENaCs in the cells of the DCT. There are definitely plenty expressed in the cells of the connecting tubule (initial collecting tubule), which is very close to the DCT, but I really don't think there are any on the DCT itself... I'll check the literature and get back to you. 128.36.194.210 (talk) 01:35, 1 May 2010 (UTC)

OK I'm back (I'm 128.36.194.210, 1:35, 1 May 2010 (UTC), I just hadn't signed in). According to figure 6 of the review entitled "Sodium and calcium transport pathways along the mammalian distal nephron: from rabbit to human" by Johannes Loffing and Brigitte Kaissling inAm J Physiol Renal Physiol 284: F628-F643, 2003; doi:10.1152/ajprenal.00217.2002, there ARE in fact ENaCs in the VERY late DCT... it looks like they're practically all in the CNT and CCT, but for the sake of accuracy it should be mentioned that amiloride must act on the LATE distal convoluted tubule as well. I'll go ahead and add the word "late" before "distal convoluted tubule" in the article if that's ok with everyone. Here's a link to the article I referenced: http://ajprenal.physiology.org/cgi/content/full/284/4/F628 Leftwing (talk) 01:11, 2 May 2010 (UTC)

Expanded a little

I expanded the article a little bit but am lacking the motivation to put more information or expand it any further than I have. I hope I got the ball rolling for someone else to clean it up some more. Otherwise I will come back to it later. I think this medication is far too common to have such a short article. Aglo123 (talk) 02:40, 2 September 2016 (UTC)

"The drug is often used in conjunction with a thiazide diuretic to counteract the potassium-sparing effect"

Thiazide diuretics cause the loss of potassium, and amiloride is potassium-sparing and counteracts that potassium-losing effect, so the two drugs together can have a neutral effect on serum potassium levels. — Preceding unsigned comment added by 155.41.223.142 (talk) 23:14, 4 December 2017 (UTC)

Agreed! Looks like it has already been corrected to "potassium-losing effect." Good catch! ―Biochemistry🙴❤ 22:33, 7 June 2018 (UTC)

The introductory definition of its mechanism of action does not agree with the detailed mechanism of action below

In the top of the article, it states that "It works by increasing the amount of sodium and decreasing the amount of potassium released by the distal tubule of the kidney."

This statement is not correct, as it later states that amiloride BLOCKS sodium reabsorption (which leads to no action at the sodium/potassium ATPase exchange pump - as per Lexicomp drugs monograph for amiloride). The above first sentence implies that sodium is released at the distal tubule of the kidney, when in fact, it is just not reabsorbed.

May 17, 2020 — Preceding unsigned comment added by 174.4.25.91 (talk) 01:53, 18 May 2020 (UTC)

Fixed.sbelknap (talk) 20:45, 2 May 2021 (UTC)

Covid research

"Amilorides inhibit SARS-CoV-2 replication in vitro by targeting RNA structures" Mapsax (talk) 01:22, 29 November 2021 (UTC)