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Latest comment: 9 years ago1 comment1 person in discussion
I am a final year undergraduate Biology student and I have created this page as part of my coursework for a Science Communication module. Clara fcn (talk) 20:10, 25 March 2015 (UTC)Reply
Latest comment: 4 years ago1 comment1 person in discussion
the article is confusing because it conflates the original "ball and chain" idea with the "hinged lid" idea. The original squid work of Armstrong had 2 separate components, the removal of the inactivation of Na channels by pronase, and the analysis of open-channel block (by TEA derivatives) of noninactivatng K channels. Combining and extrapolating these 2 results Armstrong suggested the b&c idea. Subsequent work with inactivating shaker channels suggested an N-terminal ball competed with alkyl tea for the inner vestibule. Molecular work by Caterall then suggested a variant of the b&c idea for Na channels, the lid and chain between domains 3 and 4. The article doesn't really separate and clearly describe these ideas and their evolution. see Armstrong article DOI: 10.1085/jgp.201711835 Paulhummerman (talk) 20:26, 2 December 2019 (UTC)Reply
