Talk:Band 3 anion transport protein

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Latest comment: 18 years ago1 comment1 person in discussion

Apologies, didn't realise about this-I'll wait for deletion and do a proper rename to Band 3 when this page is deletedFelix-felix 12:18, 22 September 2006 (UTC)Reply

Name of this article

Latest comment: 16 years ago4 comments4 people in discussion

Does anyone know why this protein is called Band 3? It doesn't show up as a synonym in protein boxes. If it is really just the the pronounced version of BND3, maybe we should rename the article to the more common gene name (SLC4A1). Forluvoft 01:23, 4 November 2007 (UTC)Reply

Uh oh, I think this may be a case of "homonyms" in gene symbols. We might be talking about two different genes here (referenced in the two infoboxes). Entrez Gene IDs are different, chromosomal positions are different. The question is, which one is the "right" one? I left a note on Felix-felix's talk page. Hopefully he can shed some light... AndrewGNF 04:59, 5 November 2007 (UTC)Reply

It was named 'Band 3' as it was originally discovered as a large unknown third 'band' on PAGE analysis of the erythrocyte membrane [1]. This is how it is mainly referred to in the haematology literature [2], although the official name is Anion Exchanger 1 (AE1). If you want to rename the article-I'd suggest Anion Exchanger 1 with redirects from AE1 and Band 3.FelixFelix ^talk 17:00, 6 November 2007 (UTC)Reply

In the field of haematology it is still commonly referred to as Band 3. However as a molecular biology nominated protein is is referred to as Anion Exchanger 1. This title would be the apt title in the field of Protein Biochemistry as well. Thus it is another example of where different terminology can be applied to the same entity. This is common where the fields of physiology and biochemistry meet. SteveD 3rd may 2008. 16:21. —Preceding unsigned comment added by 58.168.20.223 (talk) 06:22, 3 May 2008 (UTC)Reply

Locations

This transport protein SLC4A1, in membranes of erythrocytes and kidneys, could it be the same protein that one can find on the basolateral surface of gastric parietal cells, for production of hydochloric acid (HCl)?? As far as I know it all starts with CO2 (diffuses inside parietal cell)+ H2O + carbonic anhydrase => H2CO3 -> HCO3- + H+. The Bicarbonate travels via a transport protein, that might be SLC4A1 (?), out of the parietal cell to pump Cl- inside the cell (from blood), to join with H+ out in the gastric lumen, pumped out with H+/K+ antiport. Can anyone confirm this? It could improve some of the content in the article if somebody knew this for certain.

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