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Mechanism of action and synergy
editThe article states "Benzodiazepines increase the frequency of chloride channel opening while barbiturates increase the duration that the chloride pore remains open."
I find it extremely hard to believe that these two agents differ in this sense, especially without a high quality reference. Binding of either drug increases GABA-mediated chloride conductance thourgh increasing total cloride ion influx. The frequency vs. duration approach seems to me to be an oversimplified way of explaining drug synergy, which does not serve it's purpuse and is very misleading. — Preceding unsigned comment added by 93.103.78.229 (talk) 17:19, 5 April 2015 (UTC)
Redundant treatment info
editWhy is the *entirety* of the treatment section copied into the header description? Should this just be removed? Teddy error (talk) 06:16, 10 April 2020 (UTC)
non sequitur
editThe opening line of this article "Barbiturate overdose is poisoning due to excessive doses of barbiturates", does not make sense, because it contains circular logic.
The fact that this entry 'barbiturate overdose' exists, makes me wonder whether it is necessary. I even doubt whether an entry 'drug overdose' is necessary to provide a general explanation as it would be more like a dictionary entry, rather that an enzyclopedic article.
"Barbiturate overdose" and other drug overdoses can and should be dealt with under their respective headings.
Let's keep Wikipedia clear and simple and stick to what is essential.