Talk:Bioadhesive

Merger proposal

I propose that Polyphenolic protein (PPP) be merged into Bioadhesive. (See appended for the five sentences of content.) This receiving article is in decent shape, with some active editors, and some good, reasonable recent secondary sourcing—it is an article headed in the GA direction. The incoming subject content is interesting, overlaps directly with content already in place, but is not necessarily notable enough to remain as a standalone article, and has limited editor attention going on 4 years. So, specific details/reasons the merge are:

• volume/content of incoming: PPP is, in total, five sentences (!), so lacking all context or discussion of broad import;
• sourcing of incoming: while all seeming valid, all are primary sources, and are dated, and 3 of 5 are from the same research lab;
• editor activity: the article has had one active editor (before I went in and tidied it up), and nothing had been done since initial creation (Jan 2010);
• representativeness of content: even if not OR or POV at the time (OR for interpretation of this primary lit, POV, as narrow in labs represented), it hasn't kept up with a field that's moved on by 10-15 years; and
• nomenclature: unfortunately, some of the citations early on referred to these as polyphenolic proteins, losing the message of their role in adhesion, and creating an ambiguation issue with polyphenols, a class of berry, tea, etc. natural products with health benefits (i.e., nothing at all to do with this).

So the question is: Do we count on an article not initially finished (unexpanded, lacking secondary sourcing, etc.) and that has gone by the wayside (no updating), to somehow begin to flourish despite limited attention, or do we merge it with a clear overlapping article where its content would strengthen the receiving article and create a single, focused subject venue—with an active editor base that could move the combined content toward good article status?

Bottom line, I think that the content of the two would easily merge, with the incoming material adding reasonably referenced weight to the Mussel adhesion content. At the same time, the content of this article would add substance to that topic, in terms of quality sourcing (secondary sources already here). Clearly, the levodopa-containing protein adhesin content in the Mussel protein article can be easily explained in the context of this article, and this article is of a reasonable size such that merging with the protein content will not cause article size or undue weight problems.

Here is the complete content of the proposed incoming material (after recent edits to better organize, explain, and format it). Cheers, express opinions below. (Glad to have it, or Non, merci.)

This article is about mussel and related proteins carrying oxidative PTMs associated with bioadhesion. It is not to be confused with polyphenols or phenol polymers. The small family of proteins that are sometimes referred to as polyphenolic proteins are produced by some marine invertebrates like the blue mussel, Mytilus edulis[1] by some algae'[citation needed], and by the polychaete Phragmatopoma californica.[2] These proteins contain a high level of a post-translationally modified—oxidized—form of tyrosine, L-3,4-dihydroxyphenylalanine (levodopa, L-DOPA)[2] as well as the disulfide (oxidized) form of cysteine (cystine).[1] In the zebra mussel (Dreissena polymorpha), two such proteins, Dpfp-1 and Dpfp-2, localize in the juncture between byssus threads and adhesive plaque.[3][relevant? – discuss] The presence of these proteins appear, generally, to contribute to stiffening of the materials functioning as bioadhesives.[4][[citation needed] The presence of the dihydroxyphenylalanine-moiety arises from action of a tyrosine hydroxylase-type of enzyme;[citation needed] in vitro, it has been shown that the proteins can be cross-linked (polymerized) using a mushroom tyrosinase.[5][relevant? – discuss]

Le Prof Leprof 7272 (talk) 21:42, 11 June 2014 (UTC)

Proposed merger seems fine to me. Thanks for the detailed appraisal. LloydGraham (talk) 22:26, 11 June 2014 (UTC)  Done Klbrain (talk) 21:21, 13 May 2017 (UTC)

Two dead links removed, and sentences posted here

…with tags appearing in the text.

• An increased residence time through adhesion to the mucosal surface, such as in the eye or the nose can lead to an improved absorption of the drug.

*ref name="diva-portal.org">http://www.diva-portal.org/diva/getDocument?urn_nbn_se_uu_diva-9292__fulltext.pdf</ref>

• The subsequent formation of van der Waals, hydrogen and, in the case of a positively charged polymer, electrostatic bonds between the mucins and the hydrated polymer promotes prolonged adhesion.

• ref name="diva-portal.org" />

Le Prof Leprof 7272 (talk) 22:13, 11 June 2014 (UTC)