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The chloromethylation of styrene and divinylbenzene leads to the starting materials for the Robert Bruce Merrifield Solid-phase peptide synthesis.
References
edit- RB Merrifield (1963). "Solid Phase Peptide Synthesis. I. The Synthesis of a Tetrapeptide". Journal of the American Chemical Society. 85: 2149 1963.
- Title: CHLOROMETHYLATION OF POLYSTYRENES AND STYRENE COPOLYMERS - APPLICATIONS
Author(s): CAMPS M, CHATZOPOULOS M, CAMPS JM, MONTHEARD JP Source: JOURNAL OF MACROMOLECULAR SCIENCE-REVIEWS IN MACROMOLECULAR CHEMISTRY AND PHYSICS C27 (3-4): 505-557 1987