Talk:CARD (domain)

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Reference format incorrect

Latest comment: 14 years ago1 comment1 person in discussion

The references need to be corrected to inline references.Abergabe (talk) 15:24, 21 June 2010 (UTC)Reply

Loss or Gain of function?

Latest comment: 12 years ago1 comment1 person in discussion

"Gain-of-function mutations in the intracellular NOD2 protein has been linked to increased risk for Crohn's disease." - Surprisingly, the predominance of evidence is that the Crohn's-associated mutations in NOD2 are LOSS-of-functions mutations. Specifically, cells transfected with wild-type NOD2 activate NFkB in response to the NOD2 agonist MDP; cells transfected with mutant NOD2 do not respond to MDP. A study just published (Kim et al. J Immunol 2011;187;2849-2852) seems to refute the experiment which suggested gain-of-function. Eaberry (talk) 03:53, 9 January 2012 (UTC)Reply

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