Talk:CTCF

Angiogenesis and CTCF

CTCF is now of great importance in cancer research as it has just been shown to shut down angiogenisis at Moffitt Cancer Center Angiogenisis allows cancer cells to grow their own vascular system, required for continued growth and survival If this works shows true, CTCF work could result in cancer becoming an easily managed disease. From Ray Kurzweil's newsletter an excerpt from the article fromo Moffitt Cancer Center::: Scientists say they now have a better understanding of angiogenesis, or how cancer blood vessels grow and develop, and a possible way to stop that growth, thanks to research carried out by a team of scientists from Moffitt Cancer Center, the University of Florida, Harvard University, Yale University and the Children’s Hospital of Los Angeles. ..............

“At the heart of vascular development is VEGF which, in precise doses, is an important stimulator of normal blood vessel growth,” explained Seto. “However, VEGF — probably the most important stimulator of normal and pathological blood vessel growth — is regulated by a number of factors.”

According to Seto, the study suggests that CTCF can block VEGF from being activated. So targeting CTCF may be an effective way to fine-tune VEGF and control angiogenesis. The potential to manipulate CTCF opens a window to regulate VEGF and subsequently, the potential to manage angiogenesis and cancer.

“The real significance of this work has been apparent in experiments done at the University of Florida and at Harvard University, where our colleagues used mouse models to demonstrate that depletion of CTCF produces excess angiogenesis in animals,” explained Seto. “Like finding a small key piece in a giant puzzle, it’s truly exciting.”

Ref.: Ming Tang, et al., Restraint of angiogenesis by zinc finger transcription factor CTCF-dependent chromatin insulation, PNAS, 2011; [DOI: 10.1073/pnas.1104662108]

Link to the story at Moffitt: http://www.insidemoffitt.com/content.cfm?page_id=392&press_release_id=431 — Preceding unsigned comment added by 71.66.237.28 (talk) 20:52, 30 September 2011 (UTC)

Recent edits

Concerning this edit, please note that in the previous edit, I have included much of this material in the Discovery and Function sections. Hence re-adding this material is redundant. Furthermore, I have replaced the in-line author/year citations which are somewhat ambiguous with fully formatted citations that include external PMID and DOI links so that readers may easily find the original publications. Also per WP:LEAD, the lead section should contain a short summary of what is in the rest of the article. The added material is too long and detailed for the lead.

And finally what does the following have to do with CTCF?:

“ It is becoming increasingly evident that the chromatin structure and nuclear organization play important roles in gene expression (Cremer et al., 2006; Schneider and Grosschedl, 2007). Also, the idea of genome being organized as a fractal globule, at the megabase scale is being proposed to explain the densely packed; territorial yet dynamic nucleus (Lieberman-Aiden et al., 2009). Recently, it was also proposed that: “Epigenome can modulate the effects of stochastic noise to facilitate phase transitions in development and disease” (Pujadas et al., 2012.) ”

Hence I have reverted the re-addition of this redundant and tangental material. Boghog (talk) 04:32, 23 April 2012 (UTC)