Talk:Ceftobiprole

Stereo in structure

Please check the stereo at the pyrrolidine ring —Preceding unsigned comment added by ChemSpiderMan (talk • contribs) 03:48, 26 May 2008 (UTC)

The stereochemistry in the image in this article matches the stereochemistry in the structure at the pubchem link. Do you think there is an error? -- Ed (Edgar181) 14:53, 28 May 2008 (UTC)

"Non-inferior"?

From the article:

It has been shown to be statistically non-inferior to the combination of vancomycin and ceftazidime...

I understand the term is used in the context of clinical trials,[1] but "non-inferior" certainly sounds awkward. Especially when you can just as easily say "equivalent or superior". --David Iberri (talk) 21:54, 2 August 2008 (UTC)

Agreed that non-inferior sounds weird but in statistics there's a distinct difference between non-inferior and superior. It would be incorrect to say the drug is superior to vanco/ceftazidine, but I think saying they are equivalent would be appropriate. Hojoseph99 (talk) 23:44, 27 December 2009 (UTC)

Zeftera (ceftobiprole medocaril) is discontinued in Canada

Regarding: "Ceftobiprole has been approved for use in Canada and Switzerland, and is under review by regulatory authorities in the United States, the European Union, Australia, Russia and South Africa."

Perhaps it should be mentioned that Janssen-Ortho has discontinued sales in Canada in response to recent regulatory recommendations in the United States and European Union to not approve ZEFTERA for this indication due to concerns regarding the conduct of clinical trials.

See Health Canada website for more information: http://hc-sc.gc.ca/dhp-mps/medeff/advisories-avis/prof/_2010/zeftera_nth-aah-eng.php — Preceding unsigned comment added by Undefinedobject (talk • contribs) 22:44, 21 April 2012 (UTC)

Structure

The left-hand-side of the structure is incorrect as drawn. A large number of cephems have heteroaryloxime moieties. This is not the same as the (incorrect) nitroso alkene tautomer that has been drawn. Somebody please correct this. Also, please just draw the protons at C6 and C7. And remove the wedge between C6 and the b-lactam nitrogen. It's just ugly. — Preceding unsigned comment added by 24.156.179.178 (talk) 01:23, 20 February 2016 (UTC)

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