Talk:Cell surface receptor

General sources

It might be useful to cite one or more of these in the introductory paragraph of the article.

• Molecular Biology of the Cell (Alberts textbook)
• Molecular Cell Biology (Lodish textbook)
• The Cell: A Molecular Approach (Cooper textbook)

--JWSchmidt (talk) 05:28, 31 May 2009 (UTC)

possible topics to include

• NOTCH1
• Frizzled
• Patched
• Tumor necrosis factor receptor
• Opsin
• Inositol triphosphate receptor
• Ryanodine receptor

--JWSchmidt (talk) 05:28, 31 May 2009 (UTC)

G proteins don't phosphorylate GDP

This sentence appearing twice in the Jan 2018 version of this article is wrong and should be corrected. "The α subunit can bind with guanosine diphosphate, GDP. This causes phosphorylation of the GDP to guanosine triphosphate, GTP, and activates the α subunit". G proteins do not synthesize GTP. That is next to impossible energetically. Instead, they are activated by GDP release and GTP binding, i.e. receptor mediated nucleotide exchange. If somebody could correct that, this would be great. --— J.S.^talk 10:54, 16 January 2018 (UTC)

Thanks for catching that mistake! I've fixed it. --Tryptofish (talk) 21:00, 16 January 2018 (UTC)

Narrow or wide definition of 'receptor' (COVID Angiotensin Converting Enzyme ACE as 'receptor')

Many publications are calling ACE2 (Angiotensin Converting Enzyme, 2) a 'receptor'.

As far as I can see from the discussion on this page (Cell_surface_receptor), ACE2 does not transmit any signal from the extracellular space to change signaling pathways inside the cell, so it would not fall into the definition herein of 'receptor'.

There are receptors (in this page definition) for angiotensin, and these are extremely important in biology and medicine, as small molecules that block the angiotensin receptor are a mainstay of antihypertensive treatment ('Angiotensin Receptor Blockers', ARBs, like valsartan).

It would appear to me that referring to ACE2 as a 'receptor' is incorrect and misleading, leading those with incomplete understanding of the biology to believe that ACE2 acts in the conventional manner described in this page.

I pose this general question: how do the experts in cell signaling and biology feel about calling ACE2 a 'receptor'? — Preceding unsigned comment added by 70.20.25.26 (talk) 19:48, 2 September 2020 (UTC)