Talk:Cholesteryl ester transfer protein
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editMany professional publications, including the references, refer to this protein as "cholesteryl ester transfer protein", with a space between cholesteryl and ester. Chemically, I suspect it should be one word. Anyone an idea about this? JFW | T@lk 09:46, 20 November 2005 (UTC)
Should we carry on fiddling with HDL
editPMID 17699012 doesn't think so. JFW | T@lk 12:57, 4 November 2007 (UTC)
Homoexchange purpose?
editI find the intro paragraph confusing and don't see explanation in the body of text:
- What main purpose does CETP serve?
- What good (to the body) is a homoexchange ("trading a triglyceride for a triglyceride or a cholesteryl ester for a cholesteryl ester") between HDL and VLDL?
- By the description here, both VLDL and HDL are largely unchanged after CETP does its thing. So how does inhibiting CETP change the level of either?
According to the title of the first ref (Zhong S) increasing CETP function increased HDL. So how does torcetrapib lowering CETP increase HDL?
—(updated) David.Throop (talk) 03:58, 18 November 2007 (UTC)
We need someone who knows the topic to look at the 20 Jan 2012 change. It has to be wrong or the 'or' clause is redundant. But I don't know whether to revert the change or to make it 'trading a triglyceride for a cholesteryl ester or a cholesteryl ester for a triglyceride' I lean towards revert, but.... Thanks — Preceding unsigned comment added by 134.187.128.110 (talk) 00:34, 25 January 2012 (UTC)
Useful source
editdoi:10.1194/jlr.R400007-JLR200 outlines CETP vs atherosclerosis. This predates the torcetratib debacle. JFW | T@lk 23:57, 2 April 2008 (UTC)
Long Life
editThere are some rather exciting studies which have CETP linked to long life, good heart health, a reduced risk of cognitive decline with age and a smaller chance of developing Alzheimer's disease. Very cool, if true! It is mentioned in an article in reuters:
http://health.yahoo.com/news/reuters/us_age_genes.html I'd like to see this mentioned (preferably by someone who is very familiar with this sort of science). Gingermint (talk) 19:11, 27 April 2010 (UTC)