Talk:Choriocarcinoma

Wiki Education Foundation-supported course assignment

This article was the subject of a Wiki Education Foundation-supported course assignment, between 29 June 2020 and 21 August 2020. Further details are available on the course page. Student editor(s): Cvo.UCSF, Vtran1337, Tvu2020, Vmelgarejocovarrubias.

Above undated message substituted from Template:Dashboard.wikiedu.org assignment by PrimeBOT (talk) 17:36, 16 January 2022 (UTC)

Foundations II 2020 Group 3 proposed edits

1. In the first paragraph under the Treatments section, the article states:

"The cure rate, even for metastatic gestational choriocarcinoma, is around 90–95%." 

There is no citation or reference for this statistic. A review article in the Rev. Bras. Ginecol. Obstet. states that cure rates are more than 90% when using chemotherapy for invasive mole and choriocarcinoma.

Reference: Biscaro A, Braga A, Berkowitz RS. Diagnosis, classification and treatment of gestational trophoblastic neoplasia. Rev Bras Ginecol Obstet. 2015;37(1):42-51. doi:10.1590/SO100-720320140005198

2. In the second paragraph under the Treatments section, the article states:

"At present, treatment with single-agent methotrexate is recommended for low-risk disease..."

It is unclear whether this single-agent treatment with methotrexate is used presently since a time is not specified and the references used are dated in 1989 and 2006. A more recent article in the World Journal of Clinical Oncology presents either single-agent methotrexate or actinomycin-D as first-line treatment for low-risk gestational trophoblastic neoplasia.

EX.

"As of 2019, treatment with either single-agent methotrexate or actinomycin-D is recommended for low-risk disease..." 

See here for the World Journal of Clinical Oncology article (2019). Cvo.UCSF (talk) 21:52, 28 July 2020 (UTC)

3. Under the Treatment section, there are photos of the four stages of choriocarcinoma. This section can be improved by providing a description of each stage and how treatments relate to each stage.

4. Adding a section on Prognosis and Diagnosis Cvo.UCSF (talk) 17:08, 30 July 2020 (UTC)

Claims about the course of choriocarcinoma metastatic to the brain and liver

While metastasis of Choriocarcinoma to the brain or liver certainly is a poor prognostic factor, I have seen cases reports of patients with metastatic choriocarcinoma to the brain that have survived. Thus, I think the claim that liver or brain metastases are typically fatal should be removed. Immunize (talk) 14:46, 20 May 2010 (UTC)

See here for one case report of a patient of metastatic Choriocarcinoma to the brain who survived with irradiation and multi-agent chemotherapy. Immunize (talk) 14:49, 20 May 2010 (UTC)

Chemotherapy/Anticancer Drugs and Choriocarcinoma

This article states in the first sentence of the first paragraph (under the treatment section)

"Choriocarcinoma is one of the tumors that is most sensitive to chemotherapy."

For more clarity the statement needs to remind the audience that "pure choriocarcinoma of the testis" has a quite high resistance to chemotherapy/anticancer drugs unlike "choriocarcinoma of the placenta"

The information is unclear without specifying the location of the Choriocarcinoma under both sections of the article "Etiology and Treatment".

EX:

"Choriocarcinoma of the placenta" is one of the tumors that is most sensitive to chemotherapy unlike ("pure choriocarcinoma of the testis")  — Preceding unsigned comment added by 72.64.116.162 (talk) 22:21, 5 August 2011 (UTC)