Talk:CimaVax-EGF

Medicine: Hematology-oncology Low‑importance

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Why the low interest?

Latest comment: 8 years ago4 comments2 people in discussion

Google indicates that this vaccine has attracted a meta-analysis by NIH. Here has nothing been added to the stub. Not being a med. professional, I can only comment as follows:

Is this vaccine available in the USA or outside of Cuba?

Rowsell Park in Buffalo has gotten a waiver from the state department to import this product from Cuba, and a relatively broad waiver. THey have not yet as of dec 2015 announced any clinical trials, but that will be the first step. Candace Johnston said on TV that they are hoping to get FDA approval for clinical use in a year (early 2017?) ( Martin | talk • contribs 13:17, 5 December 2015 (UTC))Reply

Ah no that was clinical trials in a year. Too Slow. ( Martin | talk • contribs 13:27, 5 December 2015 (UTC))Reply

My understanding from that written is that it functions by encouraging the body's own defense (immune) system to moderate cancer cell growth. The stub says it works best with patients in late stages of their disease. I believe that this is a misunderstanding. Conventionally, new medicines are usually tested on patients who are in terminal stages, so as to not shorten their lives. Such may be the case here.

Importance? Because patients who have been subjected to earlier chemotherapy are generally weakened in their immune systems by the effects of chemotherapy. Studies should be eventually made to test the effects at earlier stages of disease progression and higher vigor in the immmune system. Idealist707 (talk) 21:12, 28 October 2012 (UTC)Reply

My understanding is that it creates an auto-immune response to EGF. EGF is needed(?) by cancer cells to replicate, and this suppresses that replication. Apparently it is not a complete knock out of EGF (speculation, but based on that the injections are repeated monthly). Roswell definitely hopes to apply this as a preventative for patients at high-risk, to keep the disease from showing up at all, so before even any early stage of cancer - as you might think the term vaccine implies - or the recurrence of cancer after treatment. ( Martin | talk • contribs 13:17, 5 December 2015 (UTC))Reply

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