Talk:Click chemistry

Linus Pauling?

I looked at the PNAS paper referenced in the first line of the page as of today: "Click chemistry is a chemical philosophy first recognized by Linus Pauling in 1933." I did not find any evidence to support Pauling's involvement in developing the reaction philosophy now known as click chemistry; the referenced paper appears to address molecular structures of methyl azide and carbon suboxide. The textual reference to Pauling and PNAS citation were deleted by 108.56.185.171 earlier today on the same grounds, but have been reinstated with no explanation by 159.14.241.230. I have removed the problematic edit until firmer evidence is added. Please do not engage in edit warring.

If anyone is aware of Pauling's actual involvement in the development of click chemistry, please add that information.Kmva (talk) 21:04, 7 May 2012 (UTC)

Sulfur(VI) Fluoride Exchange

A new kind of click reaction has been discovered between thionyl tetrafluoride and primary amines. SOF4 is not currently commercially available and there are no applications as of yet but is it worth mentioning in this page? I've already made a little section in the thionyl tetrafluoride page. Gsurfer04 (talk) 12:22, 16 February 2017 (UTC)

References

External links modified

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• Added archive https://web.archive.org/web/20120430070833/http://www.integrated-diagnostics.com/press-releases/barry-sharpless-click-chemistry/ to http://www.integrated-diagnostics.com/press-releases/barry-sharpless-click-chemistry/

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Layman explanation

As a non-chemist, I find the current click chemistry article aimed at far too high a technical level to understand why it is so useful and important that it won the 2022 Nobel Prize; it could use a section popularizing it. Some popular writeups to take inspiration from: https://www.science.org/content/blog-post/2022-nobel-prize-chemistry https://www.nobelprize.org/uploads/2022/10/popular-chemistryprize2022.pdf https://www.nytimes.com/2022/10/05/science/nobel-prize-chemistry-winner.html --Gwern (contribs) 20:07 5 October 2022 (GMT)