Talk:Cri du chat syndrome

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note

A lot of these kids have self stimulating behaviors such as pulling their hair, banging their head, and hitting themselves I know from first hand experience, my daughter has cri du chat. Her break was de novo and our genetics Dr. could not tell us whose genetic material was missing. If the break is de novo, there is no one to blame. —Preceding unsigned comment added by 72.49.19.115 (talk) 03:58, 10 March 2008 (UTC)

cri du chat

"Unjust"? Should that be "adjustment"? --belg4mit 18.124.2.224 23:37, 21 May 2006 (UTC)

I took out "Apparently, many enjoy pulling hair.". It sounds too condescending, almost as if the patients are being riduculed. Also, such a statement is not characteristic of an encylopedia entry.

De Novo mutation origins

The article as currently written claims that in de novo cases of 5p- deletion, the de novo mutation is of paternal origin in about 80% of the cases. Is there a cite to a reputable study for this statistic? In the case of a de novo mutation, how do you determine whether it was of maternal or paternal origin anyway? —The preceding unsigned comment was added by 24.118.231.156 (talk) 02:07, 12 February 2007 (UTC).

do they have any gut problems?

Ive been told that they lose the telomerase gene, which would definitely not be good for their sperm. Are there any cases of children with cri-du-chat fathers? —Preceding unsigned comment added by 220.245.132.115 (talk) 09:47, 22 March 2008 (UTC)

My unborn son has been diagnosed with chri-du-chat & other than what I read on internet, I just don't know much about & they are telling me won't know sevierety until birth. Any comments of experience that may help or give me true insite? —Preceding unsigned comment added by 98.228.16.81 (talk) 15:24, 22 November 2009 (UTC)

Life expectancy

What is the life expectancy for patients with Lejeune’s syndrome? -ErinHowarth (talk) 00:17, 26 November 2009 (UTC)

The above question was probably asked because of the reference in the [Telomerase reverse transcriptase] article. Telomerase is of course essential for embryonic growth and the maintenance of stem cells. If part of the telomerase structure is actually deleted from the chromosomal DNA, you would expect a severe decrease in life expectancy. Telomerase activity is necessary for maintaining telomere length in spermatogenesis, this could partially explain "In males, testes are often small, but spermatogenesis is thought to be normal.".Redtails (talk) 14:10, 4 December 2010 (UTC)