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I'm
editI'm not exactly sure what the last (previously only) paragraph refers to. Out of respect to the original author and ignorance of the material they present, I will leave it be, but would someone who knows more about immunology please investigate further?
- From my knowledge of medicine which is somewhat limited although it is an interest of mine it looks like an explaination of the theoretical mechanism behind cross tolerance however I do not have sufficient knowledge to be sure or to give it some much needed expansion, if the mechanism is to be described it really should be dealt with more fully than that, I hope someone with the required knowledge will be able to expand on that. MttJocy 12:02, 5 May 2006 (UTC)
The last paragraph refers to a completely different phenomenon of antigen presentation that has to do with immune anergy to perceived self antigens. It is the result of cross-presentation of 'self' antigen. There is a good little cross-presentation article. This phenomena should have a totally different page from pharmacological cross-tolerance as the two are unrelated.
The first part of the article is about common pathways in the durg affected cell being deactivated/downregulated. The last paragraph is about immune cells being tolerant to certain proteins/peptides. I hope this helps. I don't often edit/discuss articles. Maybe someone can use what I've said and incorporate it in. DanMcScience 01:46, 17 April 2007 (UTC)
- I agree, although there are a vast quantity of inaccuracies in both this paragraph and the cross-presentation article. the line here "This mechanism was proposed to silence autoreactive T cells that have escaped negative selection in the thymus." is totally wrong, it is the mechanism of the negative selection, thymocytes which escape the negative selection are dealt with by Treg cells in the periphery. Other than that the cross-presentation article seems to have been written by someone who has no clue what it is and has totally misunderstood the contents of the references. Cross-priming isn't even a synonym for cross presentation, they are subtly different (one is the process of moving antigen around in a dendritic cell, one is the presentation of the exogenous antigen-MHC class I complex to the thymocytes as part of the thymic education of CD8 cells). I'd make edits but to be honest the pages need scrapping.--KX36 (talk) 17:40, 13 April 2008 (UTC)