Talk:Curtin–Hammett principle
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editInitial Comments:
The article is reasonably laid out, but could use more details.
Suggestions:
- Check this link out: http://evans.harvard.edu/pdf/smnr_2009_WZOREK_JOSEPH.pdf See also the classic review by Seeman in Chem. Rev.
- Your article would benefit greatly from figures of kinetic simulations generated in COPASI. Come talk to me if you want help using it. It would be nice to see the limiting cases of kinetic quench and Curtin-Hammett control illustrated, as well as intermediate scenarios.
- Actually, the product ratio also depends on the energies of the starting materials as shown by your derivation (k2/k1 * K), not k2/k1. Why? People are commonly confused by whether it is the absolute height of a barrier that matters, the relative barrier from the last minimum, or something else. Which of these is the "rate-determining step"?
Structure error in Kapakahines Section
editI'm pretty sure there's an error in the figure showing the Synthesis of Kapakahines B and F. My focus is on the indole-pyrrole (6-5-5 ring system) and the indole-pyridone (6-5-6 ring system).
- 655 and 656 interconvert as shown by the top equilibrium arrows.
- 655 is more stable than 656 as shown by the top equilibrium arrows.
- 655 is less reactive and 656 is more reactive as shown by the "slower" - "faster" labels.
However,
- 655 should form 6% of the 655 product (currently drawn below the 656 intermediate).
- 656 should form 64% of the 656 product (currently drawn below the 655 intermediate).
A very nice write up and drawing but I think the products below "slower" and "faster" are reversed.
The kapakahines are 6-5-6 indole-pyridones, not 6-5-5 indole-pyrroles. AdderUser (talk) 18:07, 29 February 2012 (UTC)
External links modified
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- Added archive https://web.archive.org/web/20120402124752/http://evans.harvard.edu/pdf/smnr_2009_WZOREK_JOSEPH.pdf to http://evans.harvard.edu/pdf/smnr_2009_wzorek_joseph.pdf
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