Talk:Dapsone

mechanism

you haven't very well explained how it helps in bullous skin disorders. please describe the mechinsm. ta. —Preceding unsigned comment added by 129.215.5.254 (talk) 20:25, 20 May 2009 (UTC)

Dapsone

I have mentioned that Dapsone is used in combination with rifampicin and Clofazimine as part of MDT for leprosy, as it is should never be used as monotherapy, due to wudespread resistance of m.leprae.--WHO Leprosy 15:52, 24 March 2007 (UTC)

has a new use as topical 5% gel for acne aczone---needs to be added into page —Preceding unsigned comment added by 76.212.226.78 (talk) 04:17, 21 January 2009 (UTC)

Dapsone common use Gel or Pill form

Treatment/management of Dermatitis herpetiformis an autoimmune blistering disorder associated with a gluten sensitivity —Preceding unsigned comment added by Lizzz 34 (talk • contribs) 05:01, 12 September 2009 (UTC)

Mechanism of Dapsone

This was added, then deleted by KeepBusy:

Dapsone has profound anti-inflammatory effects, which are the basis for clinical work in Alzheimer disease . Dapsone is a potent blocker of myeloperoxidase (many references available) and MPO inhibition is indeed the mechanism proposed for dapsone's protective effect on nerve tissue.

Currently, editors of Dapsone have done a very poor job of representing the known mechanisms of dapsone, and my entry was a start. Dapsone's effects on MPO are profound, well documented for many years (back to 1978 or earlier), un-contested in the literature, and critical to dapsone's actions in treating pemphigus, DH, and other skin diseases, and experimentally in stroke, Alzheimer disease, and COPD. You are encouraged to edit constructively and improve my entries on wikipedia KeepBusy, not vandalize them. Thanks.--Infinitesimus (talk) 18:08, 17 December 2009 (UTC)

References

Systemic Lupus Erythematosus

Does anyone have any knowledge of the use of Dapsone in treating SLE? I see that one of the citations mentions SLE, but there is no mention of it in the body of this article.Ian Glenn (talk) 22:57, 21 March 2010 (UTC)

Type or category? What is this stuff??

Unlike other articles, the first line (and indeed the whole article) fails to categorize or type the drug. Compare to "Rifampicin ... is a bactericidal antibiotic drug of the rifamycin group" or "Clofazimine is a fat-soluble riminophenazine dye used in combination with rifampicin and dapsone as multidrug therapy (MDT) for the treatment of leprosy." or even "Aspirin ... is a salicylate drug, often used as an analgesic..."

Unfortunately, I don't what this stuff is, and my quick research online was not fruitful. The article implies it is a dye. Is there a category there? It's a sulfone, but that's more just a description of the chemical structure and not a true category, right?

Maybe this is related to our ignorance of the mechanism.

Or maybe there is no category or type. Shouldn't the first line then state that it is a unique or one of a kind drug? Anyway, somebody who knows could vastly improve the article with just a few minor edits.TjoeC (talk) 18:01, 12 February 2011 (UTC)

+1 Riventree (talk) 07:08, 31 May 2018 (UTC)

Older references, too many in places

It may be worth moving to newer references following MEDRS where appropriate, and remove the perhaps overreferencing on some statements where a current review article covers it. Subject to checking by a domain expert the following may be a candidate.

• Wozel G, Blasum C (March 2014). "Dapsone in dermatology and beyond". Arch Dermatol Res. 306 (2): 103–24. doi:10.1007/s00403-013-1409-7. PMC 3927068. PMID 24310318.

review[pt] dapsone on Pubmed gives 697 results. Similarly the following ref may be appropriate to include

• Luzzatto L, Seneca E (February 2014). "G6PD deficiency: a classic example of pharmacogenetics with on-going clinical implications". Br J Haematol. 164 (4): 469–80. doi:10.1111/bjh.12665. PMC 4153881. PMID 24372186. On the public health side, it is no longer permissible – not that we think it ever was – to sweep the issue under the carpet when administering primaquine or dapsone widely in areas where G6PD deficiency has a high prevalence: until alternative drugs become available, G6PD testing must be made available.

RDBrown (talk) 11:32, 31 January 2015 (UTC)

External links modified

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External links modified

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Synthesis diagram (historical) seems wrong

Claims to start from 4,4-thiodianiline, but those are nitrate groups not amine groups. The chromium oxidation might (?) convert the amines to nitrates, but it should still show The Right Thing to start with.

Riventree (talk) 07:08, 31 May 2018 (UTC)