Talk:Desloratadine

comment

Although its article does not include dosage information, Desloratadine itself is quite versatile. It does not cause drowsiness (mechanism of action) and it does cause drowsiness (side effects). The principle underlying this action should be documented and applied more widely. If the principle can be sufficiently generalized to be applied to things other than drugs, the possibilities are endless. One could spend money today and still have it to spend it tomorrow. One could be married and single. One could be here and there. More research is needed. Quickly. Jm546 15:25, 28 January 2006 (UTC)

I was just going to point out this contradiction, but you did it so much better than I ever could have. Now if only I knew enough to fix it. 76.202.57.153 02:33, 16 May 2007 (UTC)

Very well put, but the issue is actually more subtle than that. Drowsiness as a side effect is less likely with (des)?loratadine than with so-called first generation antihistamines. According to at least one source, drowsiness is a "less common" side effect (although that refers to an absolute scale). l0b0 (talk) 07:33, 15 April 2015 (UTC)

Actually there is evidence that fexofenadine is more effective than desloratadine at least for preventing wheal and flare reactions caused by histamine injections so i would like to debate the notion which mentions desloratadine is evenly effective as fexofenadine.

Meltzer et al.: Efficacy of fexofenadine versus desloratadine in suppressing histamine-induced wheal and flare. Allergy Asthma Proc. 2007 Jan-Feb;28(1):67-73.

PATENT STATUS: It would be useful to include patent status of this drug in various countries. Also, the history of its introduction, as on the Loratadine page (i.e. it was introduced by Schering because loratadine went off patent) —Preceding unsigned comment added by 98.231.12.80 (talk) 00:53, 26 August 2009 (UTC)

"equal or better satisfaction with desloratadine"

I think this section is worded in a misleading way that seems to suggest that patients who switched to desloratadine were more satisfied. In fact, the article says that patients who switch to desloratadine were more satisfied than patients who switched to fexofenadine. — Preceding unsigned comment added by 99.248.140.230 (talk) 04:39, 4 September 2011 (UTC)

Also, "greater levels of satisfaction amongst loratadine dissatisfied patients who converted to desloratadine" sounds like they have just committed a common statistical blunder. To spell it out, if you take human subjects who are known to be dissatisfied with X and tell them you are giving them Y (which actually has the same effect as X), you are likely to get a more favourable reception of Y. l0b0 (talk) 07:42, 15 April 2015 (UTC)

Is this a different drug

The pharamacists I've spoken with say this drug Clarinx is is nothing more than Claritan. But the body breaks this drug down to make Claritan. It is simply a way for the drug company to make more money as you have to prescribe this —Preceding unsigned comment added by 4.142.123.247 (talk) 14:54, 9 March 2008 (UTC)

I assume you’re referring to Clarinex (desloratadine) and Claritin (loratadine). Desloratadine is a metabolite of loratadine (Claritin). They’re virtually the same, so there’s no particular reason to take one rather than the other – except when you consider cost. If you’re faced with a choice between loratadine and desloratadine, and your insurance co-pay for desloratadine (currently still prescription-only) is less than the price for over-the-counter loratadine (as is generally the case), you’re obviously better off with desloratadine.

However, if you’re looking for the least-drowsy antihistamine, I’ve heard that fexofenadine (Allegra) is the best. I’ll be trying it myself soon as a replacement for cetirizine (Zyrtec), which I think has been been making me drowsy.

Disclaimer: I’m not a doctor, so you should take what I say with a grain of salt – your doctor is always the best source of medical information.

BTW: The article discussion pages here at Wikipedia are for discussing the articles themselves – not the topics they pertain to. Please use Yahoo! Answers or a similar site next time (see Wikipedia:Talk page guidelines).

Regards,
Wulf (talk) 03:44, 14 March 2008 (UTC)

MY OPINION AS A CHEMIST

I worked as a med. representative in Egypt on a generic desloratidine drug and I listened to the feedback of patients on such drug comparing to loratidine and they were very positive and the price was affordable also ..I think if desloratidine is produced with affordable price and good quality it will be so much better than its parent loratidine

41.206.157.216 (talk) 16:13, 24 July 2011 (UTC)Dr.Moh.osman(osmanic acid) pharmacist

Are these kinds of "expert opinions" even allowed here? This statement is extremely misleading to laypeople and of absolutely no statistical value. l0b0 (talk) 07:45, 15 April 2015 (UTC)

Well, the active part of loratadine is only its metabolite, desloratadine, so there is no point of making the liver work hard on creating small amount of the active ingredient of you can manufacture and sell it outright. As of 2022, 5mg tablets of desloratadine are available without prescription now in the EU, which means it was recognized as safe and harmless enough to be made available as OTC medication. 178.143.124.90 (talk) 08:11, 7 May 2022 (UTC)

Dosing: 2.5mg=no benefit, 5mg=benefit, >5mg=no additional benefit but more side-effects

Dosing:

http://www.drugs.com/pro/desloratadine.html

The recommended dose is one 5mg once daily. Desloratadine 2.5 to 20 mg/day was studied. Doses of 5, 7.5, 10, and 20 mg/day were superior to placebo, so 2.5mg wasn't. No additional benefit was seen at doses above 5mg. In the same study, an increase in the incidence of somnolence(=sleepiness) was observed at doses of 10mg/day and 20mg/day (5.2% and 7.6%, respectively), compared to placebo (2.3%).

--91.159.191.219 (talk) 15:36, 3 November 2021 (UTC)

RX status

As of 2022, the 5mg desloratadine is available in the EU without a prescription, YMMV. — Preceding unsigned comment added by 178.143.124.90 (talk) 08:06, 7 May 2022 (UTC)