Talk:Directed ortho metalation

I'm not sure if the context of this article is right for it, but closely related α-metalation (of, e.g., thiophene and furan, in which the heteroatom facilitates deprotonation at the adjacent carbon) could fit in well on this page and should be mentioned either here or on its own page. Also, the mechanism of ortho-lithiation is actually pretty interesting; there is a distinction made between kinetically controlled "coordination-only" lithiation and thermodynamically controlled "acid-base" lithiation in which the substituent affects the acidity of the aromatic ring protons only through induction, not by coordinating to the base. Inclusion of this concept would be awesome for this page. See p. 10-12 of this review. --OrganicReactions (talk) 17:26, 9 July 2010 (UTC)

Nicotinamide lithiation figure error

This figure references 10.1021/jo0620359, where the lithiation is performed on the tertiary diethyl amide, not the primary. With the latter, this reaction would almost certainly not proceed. --129.105.149.247 (talk) 22:30, 24 January 2017 (UTC)

A replacement is on its way V8rik (talk) 17:40, 25 January 2017 (UTC)

Fixed V8rik (talk) 09:44, 18 March 2017 (UTC)

Direct / Directing Metalating Group

I am not a native english speaker, so I don't know wheteher or not I am right. As I feel it, the first word word should read "Directing" in stead of "Direct". Can anyone clearify this? T.vanschaik (talk) 15:43, 15 March 2011 (UTC)

• The article name "Directed ortho metalation" corresponds to the 1990 review (ref 1) V8rik (talk) 22:30, 15 March 2011 (UTC)