Talk:Excitatory amino acid transporter 1

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Totally wrong

Latest comment: 15 years ago1 comment1 person in discussion

in your malate-aspartate-shuttle pathway, you link
the glutamate-aspartate-transporter with SLC1A3 but
this is the wrong gene, it should be SLC25A12 and SLC25A13
(isoforms). Example papers where you can see this
are PMID 17497669, PMID 12111366, PMID 12763579.

You can see also that SLC1A3 is wrong because its
protein is a symporter, not an antiporter as required
in the shuttle.

Regards,

--Ayacop (talk) 16:35, 11 November 2008 (UTC)Reply

Assessment comment

The comment(s) below were originally left at Talk:Excitatory amino acid transporter 1/Comments, and are posted here for posterity. Following several discussions in past years, these subpages are now deprecated. The comments may be irrelevant or outdated; if so, please feel free to remove this section.

Warning: There is a strong mistake in this page I will try to correct. GLAST/EAAT1 glutamate transporter (expressed in astrocytes) is NOT the same protein as SLC25A12/glutamate-aspartate mitochondrial exchanger!!

In human: GLAST gene is located on chromosome 5p13, on 109.85kb and is composed of 10 exons. SLC25A12 gene is located on chromosome 2q24-q13, on 81.68kb and is composed of 18 exons.

THIS MAY BE VERY CONFUSING!!!

Last edited at 13:12, 6 February 2008 (UTC). Substituted at 16:25, 29 April 2016 (UTC)

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