Talk:Familial Mediterranean fever
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note
editWith regard to ethnic indicators, the cited article is not the best one, and the current description is misleading. Recent research suggests that Ashkenazi Jews are, in fact, carriers of FMF at the rate of approximately 20 percent. See "Mutation and Haplotype Studies of Familial Mediterranean Fever Reveal New Ancestral Relationships and Evidence for a High Carrier Frequency with Reduced Penetrance in the Ashkenazi Jewish Population", Am. J. Hum. Genet. 64:949–962, 1999, <http://www.journals.uchicago.edu/AJHG/journal/issues/v64n4/980834/980834.web.pdf>.
Metaraminol Provocative Test (MPT
editI have not found this recommended in any of the current literature. Ben-Chetrit et al have presented contradictory findings in 1990 in a letter to the editor (Lancet)[1]. There does not seem to have been much discussion on the subject since.
References
- ^ (Ben-Chetrit, Eldad; Gutman, Alisa; Levy, Micha (1990). "Dopamine-β-hydroxylase activity in familial Mediterranean fever". The Lancet. 335 (8682): 176–176. doi:10.1016/0140-6736(90)90055-A. ISSN 0140-6736.
Anakinra
editAnn Intern Med this week - Anakinra helps if colchicine fails or is poorly tolerated. JFW | T@lk 22:37, 4 June 2007 (UTC)
- Or rilonacept doi:10.7326/0003-4819-157-8-201210160-00003. Same journal incidentally. JFW | T@lk 23:20, 17 February 2014 (UTC)
Review
editdoi:10.1111/j.1365-2141.2009.07733.x - Br J Haematol JFW | T@lk 19:40, 12 August 2009 (UTC)
Added
editThis was added:
- Some research has been done to investigate the connection of amyloidosis and Familial Mediterranean Fever, and studies have found that an important variation in this particular complication arises from the Met694Val and Val726Ala mutations. More specifically, individuals who are homozygous for Val726Ala seem to be protected from developing amyloidosis, while those who are homozygous for Met694Val or compound heterozygous for Val726Ala are susceptible. However, there is evidence to suggest that those who are heterozygous for Val726Ala may respond well to regular treatment with colchicine, thus preventing them from developing renal amyloidosis.[1]
This needs a secondary source. JFW | T@lk 10:58, 6 December 2020 (UTC)
References
- ^ Yalçinkaya, F., MD, Akar, N., M.D., & Misirliolu, M. (1998). Familial mediterranean fever--amyloidosis and the Val726Ala mutation [letter]. The New England Journal of Medicine, 338(14), 993-994.
Unsourced anecdotal symptoms
editI recently removed some unsourced information added by a Wikipedia user who personally experiences familial Mediterranean fever. I was unable to find any external source to substantiate their experiences, but have added a message to their talk page to prompt for further information. If anyone feels this should be reinstated, just let me know so we can avoid a removal war! Guidance is available on which sources are appropriate. --AlexVojProc (talk) 22:55, 19 May 2022 (UTC)
"Epidemiology of Familial Mediterranean fever in the United States of America" listed at Redirects for discussion
edit
The redirect Epidemiology of Familial Mediterranean fever in the United States of America has been listed at redirects for discussion to determine whether its use and function meets the redirect guidelines. Readers of this page are welcome to comment on this redirect at Wikipedia:Redirects for discussion/Log/2023 November 6 § Epidemiology of Familial Mediterranean fever in the United States of America until a consensus is reached. Fram (talk) 08:46, 6 November 2023 (UTC)