Talk:Fas receptor

PDB IDs

Hi! I'm relatively new in this and I don't know how to change the info box (the one with the picture and the basic information on the right). I'm a student of Biochemistry and Molecular Biology at URV, and I've been looking at the PDB's IDs given here, and the one named 3EWT is NOT a Fas receptor, but a Calmodulin-Calcium complex. If anyone can solve this little thing I'll be so glad ^_^ Anyway, if I find a moment to learn the wiki-editing stuff, I will change it myself... --Elernaw (talk) 19:37, 2 May 2017 (UTC)

name

Hi! What does Fas actually stand for? Couldn't find it anywhere, does anyone know that (at all)? Cheers —Preceding unsigned comment added by 84.161.255.16 (talk • contribs)

Well in an intirely unscientific attempt, here's Google Answer's attempt: http://answers.google.com/answers/threadview?id=492790 Down the bottom it gives FAS as "Apoptosis Stimulating Fragment", which I would be inclined to go for. A quick search of the scientific literature proved fruitless but I stress that it was very quick! Hope that helps -- Serephine ♠ talk - 02:55, 30 April 2007 (UTC)

In another quick attempt, the earliest reference I was able to find to Fas is PMC 2189304, where it is written "a mAb with cell-killing activity (termed anti-Fas)". It is further stated that "Preparation of mAb BALB/c female mice were immunized with the human diploid fibroblast FS-7 cellline and the spleen cells from immunized mice were fused with the NS-1 mouse myeloma line by standard hybridization technique (15). One hybridoma cell, producing an mAb with cell-killing activity (termed anti-Fas), was cloned two times by limiting dilution." Hence the origin of the term Fas apparently arises from fibroblast. If this is indeed the first use of the term, the origin of the acronym is very obscure and not directly related to the function but rather how it was discovered. Boghog (talk) 18:59, 14 October 2011 (UTC)

I am wondering about the name. In literature there is NO Fasreceptor. It is juste called Fas. I think the name should be changed into Fas. In the description it can be said that Fas is the receptor for FasL. Do you agree? — Preceding unsigned comment added by 193.175.244.3 (talk) 15:40, 7 May 2013 (UTC)

See FAS+Receptor at the U.S. National Library of Medicine Medical Subject Headings (MeSH) (FAS receptor is listed as an entry term), so it appear that FAS receptor has been used in the scientific literature. Boghog (talk) 19:07, 7 May 2013 (UTC)

"First apoptosis signal" is a term found in some (though not many) peer-reviewed scientific articles (searchable in quotation marks on PubMed-NCBI).

--Felix Tritschler (talk) 12:17, 3 April 2020 (UTC)

Article Today Linking Misregulation of This Protein to Skin Inflammation Disorders

Here's the article, http://www.sciencedaily.com/releases/2011/10/111013121512.htm

And here is the citation-- Marion C. Bonnet, Daniela Preukschat, Patrick-Simon Welz, Geert van Loo, Maria A. Ermolaeva, Wilhelm Bloch, Ingo Haase, Manolis Pasparakis. The Adaptor Protein FADD Protects Epidermal Keratinocytes from Necroptosis In Vivo and Prevents Skin Inflammation. Immunity, 13 October 2011 DOI: 10.1016/j.immuni.2011.08.014

69.171.160.164 (talk) 16:53, 14 October 2011 (UTC)

Dietary Influences

Anything out there on how diet can impact this protein in the body? Any citations for supplements or herbs that may regulate it?

69.171.160.164 (talk) 16:53, 14 October 2011 (UTC)